Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8
Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8
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长期给予阿卡波糖可减轻 SAMP8 小鼠的空间学习和记忆损伤，这与胰岛素系统和乙酰化 H4K8 减少的减轻有关
DOI：
10.1016/j.brainres.2015.01.042
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发表时间：
2015-04
期刊：
影响因子：
2.9
通讯作者：
Tao Fei
中科院分区：
文献类型：
--
作者：
Yan Wen-Wen;Chen Gui-Hai;Wang Fang;Tong Jing-Jing;Tao Fei
年龄相关记忆障碍（AAMI）不仅降低了老年人的生活质量，而且增加了社会的医疗费用。调节葡萄糖代谢、胰岛素/胰岛素样生长因子 1 (IGF-1) 系统和乙酰化组蛋白 H4 赖氨酸 8 (H4K8ac)（与认知相关的组蛋白乙酰化修饰方面研究最深入的方面之一）的方法往往可以改善 AAMI。在这里，我们使用衰老和AAMI的优秀动物模型SAMP8小鼠，研究a-葡萄糖苷酶抑制剂阿卡波糖长期治疗对AAMI的影响，并探讨血糖、胰岛素/IGF-1系统和H4K8ac是否与潜在影响相关。治疗组在行为测试前的 3 个月至 9 个月大时接受阿卡波糖（20 mg/kg/d，溶解在饮用水中），而对照组仅接受水。与年轻对照组（3月龄，n=11）相比，老年组（9月龄，n=8）空间学习记忆能力以及血清胰岛素、海马胰岛素受体（InsRs）和H4K8ac水平下降。有趣的是，与老对照组相比，阿卡波糖组（9月龄，n=9）表现出更好的空间学习和记忆能力，以及更高的胰岛素、InsRs和H4K8ac水平。空间学习和记忆的良好表现与胰岛素、InsRs和H4K8ac升高呈正相关。所有这些结果表明，长期服用阿卡波糖可以减轻 SAMP8 小鼠与年龄相关的空间学习和记忆障碍，并且胰岛素系统和 H4K8ac 的减少可能与这种减轻有关。
Age-associated memory impairment (AAMI) not only reduces the quality of life for the elderly but also increases the costs of healthcare for society. Methods that can regulate glucose metabolism, insulin/insulin-like growth factor 1 (IGF-1) system and acetylated histone H4 lysine 8 (H4K8ac), one of the most well-researched facets of histone acetylation modification associating with cognition, tend to ameliorate the AAMI. Here, we used SAMP8 mice, the excellent animal model of aging and AAMI, to study the effect of long-term treatment with acarbose, an inhibitor of a-glucosidase, on AAMI and explore whether blood glucose, insulin/IGF-1 system and H4K8ac are associated with potential effects. The treatment group received acarbose (20 mg/kg/d, dissolved in drinking water) at the age of 3-month until 9-month old before the behavioral test, and the controls only received water. Compared to the young controls (3-month-old,n=11), the old group (9-month-old,n=8) had declined abilities of spatial learning and memory and levels of serum insulin, hippocampal insulin receptors (InsRs) and H4K8ac. Interestingly, the acarbose group (9-month-old,n=9) showed better abilities of spatial learning and memory and higher levels of insulin, InsRs and H4K8ac relative to the old controls. Good performance of spatial learning and memory was positively correlated with the elevated insulin, InsRs and H4K8ac. All these results suggested that long-term administration of acarbose could alleviate the age-related impairment of spatial learning and memory in the SAMP8 mice, and the alleviated reduction of an insulin system and H4K8ac might be associated with the alleviation.
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DOI：
10.1093/gerona/glt091
发表时间：
2014-03
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Lu-meng Yang;Jing Zhang;Kunmu Zheng;Hui Shen;Xiaochun Chen
通讯作者：
Lu-meng Yang;Jing Zhang;Kunmu Zheng;Hui Shen;Xiaochun Chen
影响因子：
158.5
作者：
Nissen, Steven E.;Wolski, Kathy
通讯作者：
Wolski, Kathy
DOI：
10.3233/jad-131463
发表时间：
2014
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Wang H;Lian K;Han B;Wang Y;Kuo SH;Geng Y;Qiang J;Sun M;Wang M
通讯作者：
Wang M
影响因子：
3.1
作者：
HIELE, M;GHOOS, Y;VANTRAPPEN, G
通讯作者：
VANTRAPPEN, G
影响因子：
1.4
作者：
K. Alagiakrishnan;S. Sankaralingam;M. Ghosh;Laurie Mereu;P. Senior
通讯作者：
K. Alagiakrishnan;S. Sankaralingam;M. Ghosh;Laurie Mereu;P. Senior