Magnetoencephalographic Correlates of Perceptual State During Auditory Bistability.

Magnetoencephalographic Correlates of Perceptual State During Auditory Bistability.
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听觉双态性能期间感知状态的磁脑相关。

DOI:
10.1038/s41598-018-19287-0
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发表时间:
2018-01-17
期刊:
影响因子:
4.6
通讯作者:
Rees G
Rees G
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Sanders RD;Winston JS;Barnes GR;Rees G

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Bistability occurs when two alternative percepts can be derived from the same physical stimulus. To identify the neural correlates of specific subjective experiences we used a bistable auditory stimulus and determined whether the two perceptual states could be distinguished electrophysiologically. Fourteen participants underwent magnetoencephalography while reporting their perceptual experience while listening to a continuous bistable stream of auditory tones. Participants reported bistability with a similar overall proportion of the two alternative percepts (52% vs 48%). At the individual level, sensor space electrophysiological discrimination between the percepts was possible in 9/14 participants with canonical variate analysis (CVA) or linear support vector machine (SVM) analysis over space and time dimensions. Classification was possible in 14/14 subjects with non-linear SVM. Similar effects were noted in an unconstrained source space CVA analysis (classifying 10/14 participants), linear SVM (classifying 9/14 subjects) and non-linear SVM (classifiying 13/14 participants). Source space analysis restricted to a priori ROIs showed discrimination was possible in the right and left auditory cortex with each classification approach but in the right intraparietal sulcus this was only apparent with non-linear SVM and only in a minority of particpants. Magnetoencephalography can be used to objectively classify auditory experiences from individual subjects.
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