Survival and prognostic factors in hypertrophic cardiomyopathy: a meta-analysis.
Survival and prognostic factors in hypertrophic cardiomyopathy: a meta-analysis.
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DOI：
10.1038/s41598-017-12289-4
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发表时间：
2017-09-20
影响因子：
4.6
通讯作者：
Gao L
中科院分区：
文献类型：
--
作者：
Liu Q;Li D;Berger AE;Johns RA;Gao L
Hypertrophic cardiomyopathy (HCM) is a clinically and genetically heterogeneous disorder but data on survival rates are still conflicting and have not so far been quantitatively reviewed. The aim of this study is to conduct a meta-analysis of cohort studies to assess pooled survival rates and prognostic factors for survival in patients with HCM. Nineteen studies were included representing 12,146 HCM patients. The pooled 1-, 3-, 5- and 10-year survival rates were 98.0%, 94.3%, 82.2% and 75.0%, respectively. Among patients with HCM, age, NYHA functional class, family history of sudden death (FHSD), syncope, atrial fibrillation, non-sustained ventricular tachycardia (nsVT), maximum left ventricular wall thickness and obstruction were significant prognostic factors for cardiovascular death. For sudden cardiac death, FHSD, nsVT, and obstruction showed significant predictive values. Moreover, estimation of population attributable risk (PAR) suggested that nsVT was the strongest predictor for cardiovascular death (13.02%, 95% CI 3.60–25.91%), while left ventricular outflow tract obstruction/mid-ventricular obstruction (LVO/MVO) was the strongest predictor for all-cause death and sudden cardiac death (10.09%, 95% CI 4.72–20.42% and 16.44%, 95% CI 7.45–31.55%, respectively). These risk factors may thus be useful for identifying HCM patients who might benefit from early diagnosis and therapeutic interventions.
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影响因子：
39.3
作者：
Elliott, Perry M.;Anastasakis, Aris;Watkins, Hugh
通讯作者：
Watkins, Hugh
影响因子：
3.3
作者：
Efthimiadis, Georgios K.;Pagourelias, Efstathios D.;Styliadis, Ioannis H.
通讯作者：
Styliadis, Ioannis H.
DOI：
10.1111/j.1542-474x.2001.tb00110.x
发表时间：
2001-07-01
影响因子：
1.9
作者：
Gang, Y;Poloniecki, J;McKenna, WJ
通讯作者：
McKenna, WJ
影响因子：
2.1
作者：
Kaimoto, Satoshi;Kawasaki, Tatsuya;Matsubara, Hiroaki
通讯作者：
Matsubara, Hiroaki
影响因子：
2.8
作者：
Klarich, Kyle W.;Jost, Christine H. Attenhofer;Ommen, Steve R.
通讯作者：
Ommen, Steve R.