Dysmegakaryocytopoiesis in acute leukaemias: its predominance in myelomonocytic (M4) leukaemia and implication for poor response to chemotherapy
Dysmegakaryocytopoiesis in acute leukaemias: its predominance in myelomonocytic (M4) leukaemia and implication for poor response to chemotherapy
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急性白血病中的巨核细胞生成异常：在粒单核细胞 (M4) 白血病中占主导地位以及对化疗反应不佳的影响
DOI：
10.1111/j.1365-2141.1987.tb01328.x
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发表时间：
1987
影响因子：
6.5
通讯作者：
M. Ichimaru
中科院分区：
文献类型：
--
作者：
I. Jinnai;M. Tomonaga;K. Kuriyama;T. Matsuo;H. Nonaka;T. Amenomori;Y. Yoshida;M. Kusano;M. Tagawa;M. Ichimaru
Megakaryocytopoiesis was morphologically investigated in 129 adults with de novo acute leukaemia. Three types were identified: type I (84 cases), no detectable megakaryocytes; type II (32 cases), quantitatively preserved megakaryocytes with normal morphology; type III (13 cases): quantitatively preserved megakaryocytes but with distinct dysplastic changes such as micromegakaryocytes and megakaryocytes with multiple small separated nuclei. Type III was found in M1 (one out of 21 cases), M2 (one out of 20 cases), M4 (eight out of 24 cases), M6 (two out of four cases) and hypoplastic leukaemia (one out of 13 cases). M3 cases were all classified into type I. Most of acute lymphoid leukaemia cases (21 cases) belonged to type II. Among AML cases, the complete remission (CR) rate by intensive chemotherapy with daunorubicin and cytosine arabinoside was significantly lower in type III (11%) than in types I (87%) and II (71%). Among M4 cases, CR rates in type III (14%) was also significantly lower than those in type I (75%) and II (100%). Thus, the present study indicates the importance of recognizing dysmegakaryocytopoiesis in AML for clariflcation of the heterogeneous biology or pathophysiology of acute leukaemias and formulation of an appropriate therapeutic strategy.
源自多能干细胞的急性非淋巴细胞白血病患者的克隆完全缓解。
DOI：
10.1056/nejm198406073102307
发表时间：
1984
期刊：
The New England journal of medicine
影响因子：
--
作者：
Jacobson,RJ;Temple,MJ;Singer,JW;Raskind,W;Powell,J;Fialkow,PJ
通讯作者：
Fialkow,PJ