A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell.

A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell.
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源自多能干细胞的急性非淋巴细胞白血病患者的克隆完全缓解。

DOI:
10.1056/nejm198406073102307
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发表时间:
1984
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
Fialkow,PJ
Fialkow,PJ
中科院分区:
--
文献类型:
--
作者:
Jacobson,RJ;Temple,MJ;Singer,JW;Raskind,W;Powell,J;Fialkow,PJ

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急性非淋巴细胞白血病细胞毒治疗后缓解被认为是由于白血病细胞被选择性破坏,骨髓被正常干细胞重新增殖。化疗后骨髓细胞和培养的髓系集落的正常核型恢复支持了这一假设。123此外,在5名葡萄糖-6-磷酸脱氢酶杂合子急性非淋巴细胞白血病患者中,最初表现的白血病母细胞中仅发现单一酶型,但当患者进入临床缓解期时,在成熟的粒细胞及其受体中观察到正常的双酶表型。这些发现表明……
REMISSION after cytotoxic therapy in acute nonlymphocytic leukemia is thought to result from selective destruction of leukemic cells and repopulation of the marrow by normal stem cells. This postulate is supported by the restoration of a normal karyotype in marrow cells and cultured myeloid colonies after chemotherapy.123In addition, in five patients with acute nonlymphocytic leukemia who were heterozygous for glucose-6-phosphate dehydrogenase, only a single enzyme type was found in the leukemic blast cells on initial presentation, but when the patients entered clinical remission, a normal double-enzyme phenotype was observed in mature granulocytes and their precursors.456These findings indicated that . . .
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期刊: The New England journal of medicine
影响因子: --
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