A mechanism to prevent transformation of the Whi3 mnemon into a prion
A mechanism to prevent transformation of the Whi3 mnemon into a prion
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防止 Whi3 助记符转化为朊病毒的机制
DOI：
10.1101/2020.03.13.990119
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Lau Y
中科院分区：
文献类型：
--
作者：
Lau Y
In response to deceptive courtship, budding yeast cells escape pheromone induced cell cycle arrest through coalescence of the G1/S inhibitor Whi3 into a dominant inactive super-assembly. Strikingly, Whi3 super-assemblies remain stable over many cell cycles in the mother cells and are not passed on to the daughter cells. Thereby, Whi3 coalescence encodes memory, conferring to it the property of a mnemon (Whi3mnem), a protein which conformational change maintain a trait that is permanent in the mother cell but is not inherited by daughter cells. Mnemons share structural features with prions, which are self-templating protein conformations that are inherited by daughter cells. Yet, how the maintenance and asymmetric inheritance of Whi3mnemare achieved is unknown. Here, we report that Whi3mnemis closely associated with endoplasmic reticulum (ER) membranes and retained in the mother cell by the presence of lateral membrane diffusion barriers at the bud neck. Strikingly, barrier defects made Whi3mnempropagate in a mitotically stable manner, like a prion. Alike Whi3mnem, transformation of Whi3 into a prion required its poly-glutamine prion-like domain. Thus, we propose that Whi3mnemis in a self-templating state, lending temporal stability to the memory that it encodes, while its anchorage into the compartmentalized membranes of the ER ensures its confinement in the mother cell and prevents its infectious propagation. These results suggest that confined self-templating super-assembly is a powerful mechanism for the long-term encoding of information.
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影响因子：
3.3
作者：
I. Derkatch;Y. Chernoff;V. Kushnirov;S. Inge-Vechtomov;S. Liebman
通讯作者：
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DOI：
10.1016/s0021-9258(17)43557-5
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
--
发表时间：
2021
期刊：
Encyclopedic Dictionary of Archaeology
影响因子：
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作者：
Lina Chen;Shicheng Xu
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影响因子：
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作者：
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通讯作者：
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