Genomic analysis of Lassa virus from the 2018 surge in Nigeria
Genomic analysis of Lassa virus from the 2018 surge in Nigeria
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对 2018 年尼日利亚拉沙病毒激增的基因组分析
DOI：
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发表时间：
2018
影响因子：
158.5
通讯作者：
C. Happi
中科院分区：
文献类型：
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作者：
K. Siddle;Philomena J. Eromon;K. Barnes;Samar B. Mehta;J. Oguzie;I. Odia;S. Schaffner;S. Winnicki;R. Shah;J. Qu;S. Wohl;Patrick Brehio;C. Iruolagbe;J. Aiyepada;Eghosa Uyigue;Patience Akhilomen;G. Okonofua;Simon H. Ye;Tolulope A Kayode;Fehintola V Ajogbasile;J. Uwanibe;A. Gaye;Mambu Momoh;B. Chak;Dylan Kotliar;Amber Carter;A. Gladden;C. A. Freije;Omigie Omoregie;B. Osiemi;Ekene B Muoebonam;M. Airende;R. Enigbe;B. Ebo;Iguosadolo Nosamiefan;P. Oluniyi;M. Nekoui;E. Ogbaini;R. Garry;K. Andersen;Daniel J. Park;N. Yozwiak;G. Akpede;C. Ihekweazu;O. Tomori;S. Okogbenin;O. Folarin;P. Okokhere;B. MacInnis;Pardis C Sabeti;C. Happi
患者;2018年期间，尼日利亚拉沙热病例异常增加，引起了国家和国际公共卫生机构的关注。我们分析了来自感染患者的220个拉沙病毒基因组，其中包括来自2017-2018年传播季节的129个，以了解导致这一增长的病毒种群。尼日利亚Redeemer大学从2018年的样本中共生成了14个初始基因组，并将研究结果实时与尼日利亚疾病控制中心共享。我们发现病例的增加不是由特定的拉沙病毒株引起的，也不是由人与人之间的传播引起的。相反，数据与当地啮齿动物种群正在进行的跨物种传播一致。系统发育分析还揭示了根据地理结构构建的广泛的病毒多样性，主要河流似乎是啮齿动物水库迁移的障碍。
&NA; During 2018, an unusual increase in Lassa fever cases occurred in Nigeria, raising concern among national and international public health agencies. We analyzed 220 Lassa virus genomes from infected patients, including 129 from the 2017–2018 transmission season, to understand the viral populations underpinning the increase. A total of 14 initial genomes from 2018 samples were generated at Redeemer's University in Nigeria, and the findings were shared with the Nigerian Center for Disease Control in real time. We found that the increase in cases was not attributable to a particular Lassa virus strain or sustained by human‐to‐human transmission. Instead, the data were consistent with ongoing cross‐species transmission from local rodent populations. Phylogenetic analysis also revealed extensive viral diversity that was structured according to geography, with major rivers appearing to act as barriers to migration of the rodent reservoir.
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS