Relation of plasma tissue kallikrein levels to presence and severity of coronary artery disease in a Chinese population.
Relation of plasma tissue kallikrein levels to presence and severity of coronary artery disease in a Chinese population.
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中国人群血浆组织激肽释放酶水平与冠状动脉疾病的存在和严重程度的关系
DOI：
10.1371/journal.pone.0091780
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang DW
中科院分区：
文献类型：
--
作者：
Zhang Q;Ran X;Wang DW
目的组织激肽素（Tissue kallikrein， TK）在动物模型中具有一定的心脑血管保护作用。本研究的目的是探讨血浆TK水平与中国人冠心病（CAD）的存在和严重程度的关系。方法研究纳入898例连续冠心病患者和905例种族和地理匹配的对照组。所有患者均经血管造影证实冠心病，并以病变血管数及冠状动脉狭窄评分表示冠心病的严重程度。采用酶联免疫吸附法测定血浆TK水平。结果冠心病患者血浆TK水平显著高于对照组(0.347±。（0.82 vs. 0.256±0.087 mg/L， P<0.001），血浆TK水平升高与冠心病风险升高直接相关（OR = 3.49, 95% CI 2.90-4.19）。单因素方差分析和多变量逐步线性回归分析表明，根据血管评分（P<0.001）和狭窄评分（r = - 0.211， P<0.001）， TK水平与CAD严重程度呈负相关。结论：我们的研究结果表明，血浆中较高水平的TK与冠心病的存在有关，并且是轻度冠状动脉硬化的预测因子。
Objectives Tissue kallikrein (TK) has been shown to provide cardiovascular and cerebrovascular protective effects in animal models. The aim of this study was to investigate the relationship of plasma TK levels with the presence and severity of coronary artery disease (CAD) in the Chinese. Methods The study involved 898 consecutive CAD patients and 905 ethnically and geographically matched controls. CAD was angiographically confirmed in all the patients, and the severity of CAD was expressed by the number of affected vessel and coronary artery stenosis scores. Plasma TK levels were measured using an enzyme-linked immunosorbent assay. Results Plasma TK levels were significantly higher in CAD patients than controls (0.347±.082 vs. 0.256±0.087 mg/L, P<0.001), and elevated plasma TK levels were directly associated with a higher risk of CAD (OR = 3.49, 95% CI 2.90–4.19). One-way ANOVA and multivariable stepwise linear regression analysis demonstrated that TK levels were negatively associated with the severity of CAD according to vessel scores (P<0.001) and stenosis scores (r = −0.211, p<0.001). Conclusions Our findings suggest that higher levels of TK in plasma are associated with the presence of CAD and are a predictor of mild coronary arteriosclerosis.
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DOI：
10.1016/s0022-2828(02)00310-3
发表时间：
2003-02-01
影响因子：
5
作者：
Bell, RM;Yellon, DM
通讯作者：
Yellon, DM
影响因子：
37.8
作者：
Abramson, BL;Ando, S;Floras, JS
通讯作者：
Floras, JS
影响因子：
4.5
作者：
Moran A;Zhao D;Gu D;Coxson P;Chen CS;Cheng J;Liu J;He J;Goldman L
通讯作者：
Goldman L
影响因子：
2.7
作者：
Chao, J;Chao, L
通讯作者：
Chao, L
影响因子：
5
作者：
Koch, Matthias;Spillmann, Frank;Tschoepe, Carsten
通讯作者：
Tschoepe, Carsten