The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP.
The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP.
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DOI：
10.1111/j.1528-1167.2010.02908.x
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发表时间：
2011-01
期刊：
影响因子：
5.6
通讯作者：
Buchanan GF
中科院分区：
文献类型：
--
作者：
Richerson GB;Buchanan GF
人们越来越认识到癫痫患者还受到许多共病的影响，包括抑郁症、睡眠呼吸暂停和猝死患病率的增加。造成这些关联的机制尚不清楚。在这里，我们讨论癫痫患者血清素（5-HT）系统的潜在病理学降低了癫痫发作阈值，同时也增加了抑郁和猝死的风险。我们提出，5-HT 神经元发作后功能障碍会导致一些癫痫患者呼吸抑制和觉醒，这可能导致癫痫猝死 (SUDEP)。我们进一步将 SUDEP 和婴儿猝死综合症 (SIDS) 进行比较，它们可能具有共同的病理生理机制，并且都与 5-HT 系统的缺陷有关。
There is a growing appreciation that patients with seizures are also affected by a number of co-morbid conditions, including an increase in prevalence of depression, sleep apnea, and sudden death. The mechanisms responsible for these associations are unclear. Here we discuss the possibility that underlying pathology in the serotonin (5-HT) system of epilepsy patients lowers the threshold for seizures, while also increasing the risk of depression and sudden death. We propose that post-ictal dysfunction of 5-HT neurons causes depression of breathing and arousal in some epilepsy patients, and this can lead to sudden unexpected death in epilepsy (SUDEP). We further draw parallels between SUDEP and sudden infant death syndrome (SIDS), which may share pathophysiological mechanisms, and which have both been linked to defects in the 5-HT system.
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影响因子：
2.3
作者：
Corcoran, Andrea E.;Hodges, Matthew R.;Wu, Yuanming;Wang, Wengang;Wylie, Christie J.;Deneris, Evan S.;Richerson, George B.
通讯作者：
Richerson, George B.
影响因子：
25
作者：
Bradley, SR;Pieribone, VA;Richerson, GB
通讯作者：
Richerson, GB
影响因子：
30.8
作者：
Brennan, TJ;Seeley, WW;Tecott, LH
通讯作者：
Tecott, LH
影响因子：
4.4
作者：
Ben-Abraham, Ron;Szold, Oded;Weinbroum, Avi A.
通讯作者：
Weinbroum, Avi A.
DOI：
10.1124/jpet.106.104166
发表时间：
2006-08-01
影响因子：
3.5
作者：
Dorr, Adrienne E.;Debonnel, Guy
通讯作者：
Debonnel, Guy