Deconstructing the role of the exposome in youth suicidal ideation: Trauma, neighborhood environment, developmental and gender effects.
Deconstructing the role of the exposome in youth suicidal ideation: Trauma, neighborhood environment, developmental and gender effects.
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DOI：
10.1016/j.ynstr.2021.100314
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发表时间：
2021-05
影响因子：
5
通讯作者：
Gur RE
中科院分区：
文献类型：
--
作者：
Barzilay R;Moore TM;Calkins ME;Maliackel L;Jones JD;Boyd RC;Warrier V;Benton TD;Oquendo MA;Gur RC;Gur RE
环境(E)在解释大脑和行为发育的可变性方面起着关键作用，包括自杀意念(SI)和行为。因此，系统地研究环境暴露(即暴露组)与自杀表型之间的关系是至关重要的。在这里，我们评估了个体层面的逆境和邻里环境的作用及其交互作用(E×E)与青年SI相关。样本包括来自费城神经发育队列的年轻人(N=7,054，年龄11-21岁)，该队列调查了美国社区多样化人群的临床表型。我们研究了环境暴露与SI终生病史(n=671)的横截面关联，重点关注使用地理编码人口普查数据量化的个人水平的攻击创伤暴露(n=917)与社区水平的社会经济状况(SES)之间的相互作用。模型包括潜在的混淆和整体的精神病理学。结果表明，攻击性创伤与SI密切相关(OR=0.33，95%CI 2.7~4，P<0.01)，而低SES与SI无明显相关性(P=3.395)。攻击性和低SES在女性和青春期早期都与SI有更强的关联(所有E-X性别/年龄交互作用，p<；2.05)。在受创伤的青少年中，较低的SES与较少的SI相关，而在未受创伤的青少年中，SES对SI没有影响(攻击X SES交互作用，Wald=68.19，p=4.004)。协会仍然是总体精神病理学的重要控制因素。没有出现单一的SES变量来解释SES的调节作用。这些发现可能暗示了低SES的应激接种效应，SES高的年轻人更容易受到有害创伤-SI关联的影响。确定哪些环境因素有助于恢复能力，可能会为针对人群的自杀预防干预措施提供信息。横断面研究设计限制了因果推断。环境(E)是形成自杀意念(SI)发展的关键。我们整合了N=7,054名年轻人中个人层面的创伤暴露和社区层面的社会经济状况(SES)数据。在我们的队列中，创伤与青年SI密切相关，而SES与SI无关。只有在有攻击性创伤史的年轻人中，低SES与较低的SSI发生率(由SES相互作用造成的创伤)相关。结果表明，应激接种效应在动物模型中表现出来，但在人类自杀研究中没有表现出来。
Environment (E) is pivotal in explaining variability in brain and behavior development, including suicidal ideation (SI) and behavior. It is therefore critical to systematically study relationships among environmental exposures (i.e., exposome) and suicidal phenotypes. Here, we evaluated the role of individual-level adversity and neighborhood environment and their interaction (E x E) in association with youth SI. Sample included youth (N = 7,054, ages 11–21) from the Philadelphia Neurodevelopmental Cohort, which investigated clinical phenotypes in a diverse US community population. We examined cross-sectional associations of environmental exposures with lifetime history of SI (n = 671), focusing on interactions between individual-level exposures to assaultive trauma (n = 917) and neighborhood-level socioeconomic status (SES) quantified using geocoded Census data. Models included potential confounds and overall psychopathology. Results showed that assaultive trauma was strongly associated with SI (OR = 3.3, 95%CI 2.7–4, p < .001), while low SES was not (p = .395). Both assault and low SES showed stronger association with SI in females, and in early adolescence (all E X gender/age interactions, p < .05). In traumatized youths, lower SES was associated with less SI, with no SES effects on SI in non-traumatized youths (Assault X SES interaction, Wald = 8.19, p = .004). Associations remained significant controlling for overall psychopathology. No single SES variable emerged above others to explain the moderating effect of SES. These findings may suggest a stress inoculation effect in low SES, where youths from higher SES are more impacted by the deleterious trauma-SI association. Determining which environmental factors contribute to resilience may inform population specific suicide prevention interventions. The cross-sectional study design limits causal inferences. Environment (E) is key in shaping development of suicidal ideation (SI). We integrated individual-level trauma exposure and neighborhood-level data on socioeconomic status (SES) in N=7,054 youths. Trauma was robustly associated with youth SI in our cohort, while SES had no association with SI. Only in youth with history of assaultive trauma, low SES was associated with lower SI rates (trauma by SES interaction). Results suggest a stress inoculation effect that was shown in animal models, but has not been shown in human suicide research.
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影响因子：
6.9
作者：
Moore TM;Martin IK;Gur OM;Jackson CT;Scott JC;Calkins ME;Ruparel K;Port AM;Nivar I;Krinsky HD;Gur RE;Gur RC
通讯作者：
Gur RC
影响因子：
6.9
作者：
Barzilay, Ran;Calkins, Monica E.;Gur, Raquel E.
通讯作者：
Gur, Raquel E.
影响因子：
7.6
作者：
Allegrini, Andrea G.;Cheesman, Rosa;Plomin, Robert
通讯作者：
Plomin, Robert
影响因子：
3.3
作者：
LeBouthillier, Daniel M.;McMillan, Katherine A.;Asmundson, Gordon J. G.
通讯作者：
Asmundson, Gordon J. G.
DOI：
10.1177/070674370905400207
发表时间：
2009-02-01
影响因子：
4
作者：
Belik, Shay-Lee;Stein, Murray B.;Sareen, Jitender
通讯作者：
Sareen, Jitender