The irreversible component of persistent asthma.

The irreversible component of persistent asthma.
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DOI:
10.1016/j.jaci.2009.09.047
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发表时间:
2009-11
影响因子:
14.2
通讯作者:
Peters, Stephen P.
Peters, Stephen P.
中科院分区:
医学1区
文献类型:
--
作者:
Pascual, Rodolfo M.;Peters, Stephen P.

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不可逆转的气流阻塞或限制发生在一些哮喘患者中,可能在生命早期发展,并随着哮喘变得更加严重而变得更加常见。由于缺乏对表型的标准化定义和适当的研究模型,理解不可逆转气流障碍或限制的努力一直受到阻碍。不幸的是,目前可用的哮喘治疗似乎并不能预防这种重要的哮喘并发症。在此,我们对哮喘不可逆转成分的证据、其潜在的病理机制以及目前哮喘治疗的局限性进行了综述。
Irreversible airflow obstruction or limitation occurs in some patients with asthma, may develop early in life and becomes more common as asthma becomes more severe. Efforts to understand irreversible airflow obstruction or limitation have been hampered by the lack of a standardized definition of the phenotype and by the lack of appropriate research models. Unfortunately, it appears that currently available asthma treatments do not prevent this important asthma complication. Herein, the evidence of an irreversible component of asthma, its underlying pathology and the limitations of current asthma treatments are reviewed.
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