Impact of longitudinal status change in metabolic syndrome defined by two different criteria on new onset of type 2 diabetes in a general Japanese population: the Tanno-Sobetsu Study.
Impact of longitudinal status change in metabolic syndrome defined by two different criteria on new onset of type 2 diabetes in a general Japanese population: the Tanno-Sobetsu Study.
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DOI：
10.1186/s13098-016-0182-0
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发表时间：
2016
影响因子：
4.8
通讯作者：
Miura T
中科院分区：
文献类型：
--
作者：
Ohnishi H;Saitoh S;Akasaka H;Furukawa T;Mori M;Miura T
我们研究了日本人群中代谢综合征（MetS）的纵向状态变化对新发2型糖尿病（NODM）的影响。参与者是827名非糖尿病公民，他们在1994年和2003年或2004年接受了医疗检查。我们使用两种不同的MetS标准：6个机构的临时标准（MetS-INT）和日本标准（MetS-JP）。根据临时标准，定义为患有MetS的个体具有MetS的以下五个组分中的任何三个：肥胖、高血糖症、高血压、高胆固醇血症和低HDL胆固醇血症。根据日本标准，定义为患有MetS的个体必须具有腹部肥胖加上以下三个因素中的任何两个：高血糖症、高血压和血脂异常（高胆固醇血症和/或低HDL-胆固醇血症）。根据MetS状态的变化，将参与者分为四组：非MetS到非MetS组，非MetS到MetS组，MetS到非MetS组和MetS到MetS组。我们计算了这四组NODM的比值比。65名参与者发生NODM。NODM的优势比在non-MetS-INT与MetS-INT组、MetS-INT与non-MetS-INT组和MetS-INT与MetS-INT组中分别为4.86、4.97和7.50。另一方面，非MetS-JP与MetS-JP组和MetS-JP与MetS-JP组的比值比分别为4.28和15.55。校正基线空腹血糖后，日本标准组中MetS与MetS组的比值比大于中期标准组。定期检测代谢综合征的状态，关注代谢综合征的状态变化，对预防2型糖尿病的发生具有重要意义。将肥胖作为先决条件的标准所定义的代谢综合征可能比将肥胖作为先决条件之一的标准所定义的代谢综合征更易发生2型糖尿病。
We investigated the effect of longitudinal status change in metabolic syndrome (MetS) assessed by two different criteria on new onset of type 2 diabetes (NODM) in a Japanese population. The participants were 827 non-diabetic citizens who had undergone medical examinations in 1994 and 2003 or 2004. We used two different criteria of MetS: the interim criteria by 6 institutions (MetS-INT) and Japanese criteria (MetS-JP). According to the interim criteria, individuals defined as having MetS have any three of the following five components of MetS: obesity, hyperglycemia, high blood pressure, hypertriglyceridemia and low HDL cholesterolemia. According to the Japanese criteria, individuals defined as having MetS must have abdominal obesity plus any two of the following three factors; hyperglycemia, high blood pressure and dyslipidemia (hypertriglyceridemia and/or low HDL-cholesterolemia). According to the status change in MetS, participants were divided into four groups: a non-MetS to non-MetS group, a non-MetS to MetS group, a MetS to non-MetS group and a MetS to MetS group. We calculated odds ratios of these four groups for NODM. NODM occurred in 65 participants. The odds ratios for NODM were 4.86, 4.97 and 7.50 in the non-MetS-INT to MetS-INT group, MetS-INT to non-MetS-INT group and MetS-INT to MetS-INT group, respectively. On the other hand, the odds ratios were 4.28 and 15.55 in the non-MetS-JP to MetS-JP group and MetS-JP to MetS-JP group, respectively. After adjustment for high fasting plasma glucose at baseline, magnitude of the odds ratio of MetS to MetS group was larger in the Japanese criteria group than in the interim criteria group. Determining the status of MetS routinely and paying attention to status change in MetS may be important for prevention of type 2 diabetes. MetS defined by the criteria which includes obesity as a prerequisite component may be a stronger risk for type 2 diabetes than MetS defined by the criteria which includes obesity as one of components.
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影响因子：
16.2
作者：
Mukai N;Doi Y;Ninomiya T;Hata J;Yonemoto K;Iwase M;Iida M;Kiyohara Y
通讯作者：
Kiyohara Y
影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
16.2
作者：
Ford, ES
通讯作者：
Ford, ES
影响因子：
168.9
作者：
Sattar, Naveed;McConnachie, Alex;Wannamethee, S. Goya
通讯作者：
Wannamethee, S. Goya
影响因子：
8.2
作者：
ERIKSSON, KF;LINDGARDE, F
通讯作者：
LINDGARDE, F