Parental risk constellations and future alcohol use disorder (AUD) in offspring: A combined HUNT survey and health registries study.
Parental risk constellations and future alcohol use disorder (AUD) in offspring: A combined HUNT survey and health registries study.
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DOI：
10.1037/adb0000681
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Lund IO
中科院分区：
文献类型：
--
作者：
Burdzovic Andreas J;Ask Torvik F;Ystrom E;Skurtveit S;Handal M;Martinez P;Laslett AM;Lund IO
我们研究了具有不同父母危险因素的家庭的后代发生未来酒精使用障碍（AUD）的风险。我们分析了来自6696个双亲家庭的8,774名后代（50.2%男性）的样本，这些家庭在1995-97年或2006-08年参加了挪威的Nord-Trøndelag健康研究（HUNT），当时后代年龄在13-19岁之间。根据人口登记信息和父母的HUNT自我报告，通过潜在特征分析将家庭分为五个风险星座，反映父母的教育，饮酒量和频率以及心理健康。从3个国家健康登记处获得2008- 2016年期间所有后代的AUD相关诊断、治疗和处方信息，并汇总以反映任何AUD。使用一组嵌套逻辑回归模型检查了后代发生AUD的可能性。登记研究记录了186例（2.1%）AUD病例。与风险最低的星座相比，在未校正的分析中，来自两个星座的后代更有可能出现AUD。在调整所有协变量后，包括后代的饮酒量和在青春期目睹父母醉酒，对于来自父母双方至少每周酗酒，教育程度低和精神健康状况差的星座的后代，AUD风险仍然升高并具有统计学意义（aOR = 2.34，95%CI = 1.14 - 4.85）。在挪威，父母双方每周酗酒与社区后代未来的AUD风险相关，同时伴有其他父母风险，如精神健康状况差和教育程度低。
We examined the risk of developing a future alcohol use disorder (AUD) among offspring of families with different constellations of parental risk factors. We analyzed a sample of 8,774 offspring (50.2% male) from 6696 2-parent families who participated in the Nord-Trøndelag Health Study (HUNT) in Norway when offspring were 13–19 years old in 1995–97 or 2006–08. Based on population registry information and parental HUNT self-reports, families were classified via Latent Profile Analysis into five risk constellations reflecting both parents’ education, drinking quantities and frequencies, and mental health. Information about AUD-related diagnoses, treatments, and prescriptions for all offspring in the period between 2008–16 was obtained from 3 national health registries and pooled to reflect any AUD. The likelihood of AUD in offspring was examined with a set of nested logistic regression models. Registry records yielded 186 (2.1%) AUD cases. Compared to the lowest-risk constellation, offspring from two constellations were more likely to present with AUD in unadjusted analyses. After adjusting for all covariates, including offspring’s alcohol consumption and witnessing parental intoxication during adolescence, AUD risk remained elevated and statistically significant (aOR = 2.34, 95% CI = 1.14 – 4.85) for offspring from the constellation characterized by at least weekly binge drinking, low education, and poor mental health in both parents. Weekly binge drinking by both parents was associated with future AUD risk among community offspring in Norway when clustered with additional parental risks such as poor mental health and low educational attainment.
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