Emerging Cellular and Molecular Strategies for Enhancing Central Nervous System (CNS) Remyelination.
Emerging Cellular and Molecular Strategies for Enhancing Central Nervous System (CNS) Remyelination.
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DOI：
10.3390/brainsci8060111
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发表时间：
2018-06-15
期刊：
影响因子：
3.3
通讯作者：
Miller RH
中科院分区：
文献类型：
--
作者：
Abu-Rub M;Miller RH
髓鞘形成对于脊椎动物中枢神经系统（CNS）的正常功能至关重要。髓鞘的发育受到干扰的条件导致严重受损的个体通常具有较短的寿命，而成人中髓鞘的损失导致各种功能缺陷。虽然某些形式的自发髓鞘再生经常发生，但整个修复过程往往失败。一些证据表明，开发增强CNS进行髓鞘再生和潜在逆转功能缺陷的能力的策略是可行的。这些策略包括使用神经或间充质干细胞以及少突胶质细胞发育和分化的分子调节剂的细胞疗法。鉴于脱髓鞘疾病的流行及其对受影响个体生活质量的影响，开发有效的治疗方法势在必行。在这里，我们讨论了一些新的方法，中枢神经系统髓鞘修复，持有承诺，以减轻疾病的负担，髓鞘损失的特点。
Myelination is critical for the normal functioning of the central nervous system (CNS) in vertebrates. Conditions in which the development of myelin is perturbed result in severely compromised individuals often with shorter lifespans, while loss of myelin in the adult results in a variety of functional deficits. Although some form of spontaneous remyelination often takes place, the repair process as a whole often fails. Several lines of evidence suggest it is feasible to develop strategies that enhance the capacity of the CNS to undergo remyelination and potentially reverse functional deficits. Such strategies include cellular therapies using either neural or mesenchymal stem cells as well as molecular regulators of oligodendrocyte development and differentiation. Given the prevalence of demyelinating diseases and their effects on the quality of life for affected individuals it is imperative that effective therapies are developed. Here we discuss some of the new approaches to CNS myelin repair that hold promise for reducing the burden of diseases characterized by myelin loss.
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影响因子：
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作者：
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通讯作者：
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