Oligodendrocytes: biology and pathology.
Oligodendrocytes: biology and pathology.
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DOI：
10.1007/s00401-009-0601-5
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发表时间：
2010-01
影响因子：
12.7
通讯作者：
Lassmann H
中科院分区：
文献类型：
--
作者：
Bradl M;Lassmann H
少突胶质细胞是中枢神经系统(CNS)的髓鞘细胞。它们是细胞谱系的最终产物，细胞谱系必须经历复杂和精确的增殖、迁移、分化和髓鞘形成程序，才能最终产生轴突的绝缘鞘。由于这种复杂的分化过程，以及由于其独特的代谢/生理，少突胶质细胞是中枢神经系统中最脆弱的细胞之一。在这篇综述中，我们首先描述了最终形成成熟少突胶质细胞和髓鞘的不同步骤，正如对啮齿动物的研究所揭示的那样。然后我们将展示人类少突胶质细胞发育的不同和相似之处。最后，我们将列出在人类中枢神经系统疾病中导致少突胶质细胞和髓鞘丢失的不同途径，并揭示导致髓鞘恢复或失败的不同原理。
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons. Due to this complex differentiation program, and due to their unique metabolism/physiology, oligodendrocytes count among the most vulnerable cells of the CNS. In this review, we first describe the different steps eventually culminating in the formation of mature oligodendrocytes and myelin sheaths, as they were revealed by studies in rodents. We will then show differences and similarities of human oligodendrocyte development. Finally, we will lay out the different pathways leading to oligodendrocyte and myelin loss in human CNS diseases, and we will reveal the different principles leading to the restoration of myelin sheaths or to a failure to do so.
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影响因子：
16.2
作者：
Brinkmann, Bastian G.;Agarwal, Amit;Sereda, Michael W.;Garratt, Alistair N.;Mueller, Thomas;Wende, Hagen;Stassart, Ruth M.;Nawaz, Schanila;Humml, Christian;Velanac, Viktorija;Radyushkin, Konstantin;Goebbels, Sandra;Fischer, Tobias M.;Franklin, Robin J.;Lai, Cary;Ehrenreich, Hannelore;Birchmeier, Carmen;Schwab, Markus H.;Nave, Klaus Armin
通讯作者：
Nave, Klaus Armin
影响因子：
64.8
作者：
Bergles, DE;Roberts, JDB;Jahr, CE
通讯作者：
Jahr, CE
影响因子：
2.5
作者：
BORRELLI, E;LANGLEY, OK;GOMBOS, G
通讯作者：
GOMBOS, G
影响因子：
158.5
作者：
Chang, A;Tourtellotte, WW;Trapp, BD
通讯作者：
Trapp, BD
DOI：
10.1007/bf01189817
发表时间：
1994-01-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BERGER, T;FROTSCHER, M
通讯作者：
FROTSCHER, M