MicroRNA-mediated drug resistance in breast cancer.
MicroRNA-mediated drug resistance in breast cancer.
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DOI：
10.1007/s13148-011-0040-8
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发表时间：
2011-08
影响因子：
5.7
通讯作者：
Pogribny, Igor P.
中科院分区：
文献类型：
--
作者：
Kutanzi, Kristy R.;Yurchenko, Olga V.;Beland, Frederick A.;Checkhun, Vasyl' F.;Pogribny, Igor P.
化疗耐药是成功治疗乳腺癌需要克服的主要障碍之一。目前，提出了几种解释化疗药物耐药的机制，包括药物转运体和代谢酶介导的细胞内药物浓度降低；影响细胞周期阻滞、细胞凋亡和DNA修复的细胞反应受损；诱导促进癌细胞群进展的信号通路；DNA甲基化和组蛋白修饰的扰动；以及药物靶点可获得性的变化。遗传学和表观遗传学理论都被提出来解释耐药性的机制。最近，一个小的非编码类rna，被称为microrna，已被确定为涉及化学耐药机制的关键基因的主要调控因子。本文综述了microrna在调节化学耐药中的作用，并强调了逆转microrna介导的耐药的潜在治疗靶点。未来，基于微rna的治疗与传统化疗相结合，可能成为耐药乳腺癌临床治疗的新策略。
Chemoresistance is one of the major hurdles to overcome for the successful treatment of breast cancer. At present, there are several mechanisms proposed to explain drug resistance to chemotherapeutic agents, including decreased intracellular drug concentrations, mediated by drug transporters and metabolic enzymes; impaired cellular responses that affect cell cycle arrest, apoptosis, and DNA repair; the induction of signaling pathways that promote the progression of cancer cell populations; perturbations in DNA methylation and histone modifications; and alterations in the availability of drug targets. Both genetic and epigenetic theories have been put forward to explain the mechanisms of drug resistance. Recently, a small non-coding class of RNAs, known as microRNAs, has been identified as master regulators of key genes implicated in mechanisms of chemoresistance. This article reviews the role of microRNAs in regulating chemoresistance and highlights potential therapeutic targets for reversing miRNA-mediated drug resistance. In the future, microRNA-based treatments, in combination with traditional chemotherapy, may be a new strategy for the clinical management of drug-resistant breast cancers.
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影响因子：
5.7
作者：
Blower, Paul E.;Verducci, Joseph S.;Sadee, Wolfgang
通讯作者：
Sadee, Wolfgang
影响因子：
4.8
作者：
Bourguignon, Lilly Y. W.;Spevak, Christina C.;Gilad, Eli
通讯作者：
Gilad, Eli
影响因子：
37.3
作者：
Bandrés E;Cubedo E;Agirre X;Malumbres R;Zárate R;Ramirez N;Abajo A;Navarro A;Moreno I;Monzó M;García-Foncillas J
通讯作者：
García-Foncillas J
影响因子：
11.5
作者：
Carey, Lisa A.;Dees, E. Claire;Perou, Charles M.
通讯作者：
Perou, Charles M.
影响因子：
5.7
作者：
Cochrane DR;Spoelstra NS;Howe EN;Nordeen SK;Richer JK
通讯作者：
Richer JK