Changes in arterial stiffness and nitric oxide production with Chlorella-derived multicomponent supplementation in middle-aged and older individuals
Changes in arterial stiffness and nitric oxide production with Chlorella-derived multicomponent supplementation in middle-aged and older individuals
复制标题
小球藻衍生多成分补充剂对中老年人动脉僵硬度和一氧化氮产生的影响
DOI：
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发表时间：
2015
影响因子：
2.4
通讯作者：
S. Maeda
中科院分区：
文献类型：
--
作者：
T. Otsuki;K. Shimizu;S. Maeda
小球藻是一种单细胞绿藻，含有多种营养物质，包括氨基酸、膳食纤维、n-3不饱和脂肪酸、维生素和矿物质。我们先前证明了小球藻衍生的多组分补充剂降低了年轻男性的动脉僵硬。然而，小球藻来源的补充剂降低动脉僵硬的潜在机制以及对中老年人的影响仍未被探索。这项研究验证了我们的假设，即小球藻来源的补充剂通过增加中老年人一氧化氮(NO，一种内皮来源的松弛因子)的产生来改善动脉僵硬。32名年龄在45岁至75岁之间的受试者以双盲方式被分配到安慰剂组和小球藻组，分别服用各自的片剂4周。分别于服药前和服药后测定臂踝脉搏波传导速度(BaPWV)和血浆亚硝酸盐/硝酸盐(NOx，NO终产物)浓度。服用安慰剂前后baPWV无差异，但补充小球藻后baPWV降低。添加小球藻后BaPWV的变化与血浆NOx浓度的变化呈正相关。我们的结论是，小球藻衍生的多组分补充剂降低了中老年个体的动脉僵硬。这可能与血管内皮细胞产生的NO增多有关。
Chlorella is a unicellular green alga, which contains a variety of nutrients including amino acids, dietary fibers, n-3 unsaturated fatty acid, vitamins, and minerals. We previously demonstrated that Chlorella-derived multicomponent supplementation decreases arterial stiffness in young men. However, mechanisms underlying the reduction in arterial stiffness by Chlorella-derived supplementation and the effect in middle-aged and older individuals have remained unexplored. This study tested our hypothesis that Chlorella-derived supplementation improves arterial stiffness via an increase in nitric oxide (NO, a endothelium-derived relaxing factor) production in middle-aged and older individuals. Thirty-two subjects between 45 and 75 years of age assigned to placebo and Chlorella groups in a double-blinded manner and took respective tablets for 4 weeks. Before and after the supplementations, brachial-ankle pulse wave velocity (baPWV, an index of arterial stiffness) and plasma nitrite/nitrate (NOx, end product of NO) concentration were measured. There was no difference in baPWV between before and after the placebo intake, but baPWV decreased after the Chlorella supplementation. Changes in baPWV with the Chlorella supplementation were correlated with those in plasma NOx concentration. We concluded that Chlorella-derived multicomponent supplementation decreases arterial stiffness in middle-aged and older individuals. It may be associated with increase in NO production by vascular endothelium.
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
影响因子：
158.5
作者：
Appel, LJ;Moore, TJ;Karanja, N
通讯作者：
Karanja, N
DOI：
10.1152/ajpheart.00879.2003
发表时间：
2004-04-01
影响因子：
4.8
作者：
Eskurza, I;Monahan, KD;Seals, DR
通讯作者：
Seals, DR