A 90-channel triaxial magnetoencephalography system using optically pumped magnetometers.
A 90-channel triaxial magnetoencephalography system using optically pumped magnetometers.
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DOI：
10.1111/nyas.14890
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发表时间：
2022-11
影响因子：
5.2
通讯作者：
Brookes, Matthew J.
中科院分区：
文献类型：
--
作者：
Rea, Molly;Boto, Elena;Holmes, Niall;Hill, Ryan;Osborne, James;Rhodes, Natalie;Leggett, James;Rier, Lukas;Bowtell, Richard;Shah, Vishal;Brookes, Matthew J.
脑磁图（MEG）测量神经网络中电流产生的小磁场，提供了一种非侵入性的大脑功能度量。MEG已被公认为一种强大的神经科学和临床工具。然而，目前的仪器受到繁琐的低温场传感技术的阻碍。相比之下，使用光泵磁力计（OPM‐MEG）的MEG采用小型，轻型，非低温传感器，提供具有更高灵敏度和空间分辨率的数据，自然的扫描环境（包括参与者运动），以及对任何年龄的适应性。然而，OPM-MEG是一种新技术，设计系统的最佳方式尚不清楚。在这里，我们构建了一个新颖的90通道三轴OPM-MEG系统，并使用它来映射自然手写任务期间的运动功能。结果表明，高精度磁场控制可将背景场降低至200 pT，使参与者能够自由移动。与传统（单轴）设计相比，我们的三轴阵列可提供两倍的总测量信号和更好的干扰抑制。我们将神经振荡活动映射到感觉运动网络，证明了左手与右手手写在运动网络活动和连接方面的显着差异。扫描的可重复性表明，我们可以以0.4 mm的精度绘制电生理活动。总的来说，我们的研究引入了一种新的三轴OPM-MEG设计，并证实了其用于高性能功能神经成像的潜力。脑磁图（MEG）测量大脑中电流流动产生的微小磁场，但传统的MEG受到繁琐的低温场传感技术的阻碍。我们的可穿戴式90通道三轴光泵磁力计（OPM）MEG系统与精确的磁场控制相结合，可将背景场降低到10200 pT，用于将手写过程中的电生理活动映射到运动皮层，精度为104 mm。
Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogenic field‐sensing technologies. In contrast, MEG using optically pumped magnetometers (OPM‐MEG) employs small, lightweight, noncryogenic sensors that provide data with higher sensitivity and spatial resolution, a natural scanning environment (including participant movement), and adaptability to any age. However, OPM‐MEG is new and the optimum way to design a system is unknown. Here, we construct a novel, 90‐channel triaxial OPM‐MEG system and use it to map motor function during a naturalistic handwriting task. Results show that high‐precision magnetic field control reduced background fields to ∼200 pT, enabling free participant movement. Our triaxial array offered twice the total measured signal and better interference rejection compared to a conventional (single‐axis) design. We mapped neural oscillatory activity to the sensorimotor network, demonstrating significant differences in motor network activity and connectivity for left‐handed versus right‐handed handwriting. Repeatability across scans showed that we can map electrophysiological activity with an accuracy ∼4 mm. Overall, our study introduces a novel triaxial OPM‐MEG design and confirms its potential for high‐performance functional neuroimaging. Magnetoencephalography (MEG) measures the tiny magnetic fields generated by current flow in the brain, but conventional MEG is hampered by cumbersome cryogenic field‐sensing technologies. Our wearable, 90‐channel triaxial optically‐pumped magnetometer (OPM) MEG system—in conjunction with precision magnetic field control that reduced background fields to ∼200 pT—is used here to map electrophysiological activity during handwriting to the motor cortex, with accuracy ∼4 mm.
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影响因子：
5.7
作者：
Borna A;Iivanainen J;Carter TR;McKay J;Taulu S;Stephen J;Schwindt PDD
通讯作者：
Schwindt PDD
在头皮安装的磁刻摄影术中用于无效背景磁场的双平面线圈系统。
影响因子：
5.7
作者：
Holmes N;Leggett J;Boto E;Roberts G;Hill RM;Tierney TM;Shah V;Barnes GR;Brookes MJ;Bowtell R
通讯作者：
Bowtell R
影响因子：
3.7
作者：
Boto E;Bowtell R;Krüger P;Fromhold TM;Morris PG;Meyer SS;Barnes GR;Brookes MJ
通讯作者：
Brookes MJ
影响因子：
19.7
作者：
Feys, Odile;Corvilain, Pierre;Christiaens, Florence
通讯作者：
Christiaens, Florence
影响因子：
56.9
作者：
COHEN, D
通讯作者：
COHEN, D