Cortisol-induced hematologic and immunologic changes in channel catfish (Ictalurus punctatus).

Cortisol-induced hematologic and immunologic changes in channel catfish (Ictalurus punctatus).
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皮质醇诱导斑点叉尾鮰(Ictalurus punctatus)的血液学和免疫学变化。

DOI:
10.1016/0300-9629(87)90143-5
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发表时间:
1987
期刊:
Comparative biochemistry and physiology. A, Comparative physiology
影响因子:
--
通讯作者:
Clem,LW
Clem,LW
中科院分区:
--
文献类型:
--
作者:
Ellsaesser,CF;Clem,LW

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1.静脉注射生理剂量的皮质醇导致癍点叉尾鮰外周血白细胞的血液学和免疫学变化。这些变化模仿鲶鱼处理和运输时的急性压力。2. 18小时后,给药的皮质醇,减少循环淋巴细胞的数量和伴随的增加循环中性粒细胞的数量进行了观察,即到相同的水平,以前看到在强调鱼。3.从皮质醇注射鱼外周血白细胞的功能分析表明,剩余的淋巴细胞不再能够响应促有丝分裂刺激。4.这种抑制促有丝分裂刺激没有看到当外周血白细胞在体外培养与生理剂量的皮质醇。5.后一种观察结果表明,皮质醇单独可能不是反应性丧失的直接原因,但可能在体内作为其他事件的引发剂,最终导致观察到的免疫抑制。
1. Intravenous injections of physiologic doses of cortisol resulted in both hematologic and immunologic changes in channel catfish peripheral blood leucocytes. These changes mimicked those seen when catfish were acutely stressed by handling and transport. 2. Eighteen hours after the administration of cortisol, decreases in the number of circulating lymphocytes and concomitant increases in the number of circulating neutrophils were observed, ie to the same levels seen previously in stressed fish. 3. Functional analysis of peripheral blood leucocytes from cortisol-injected fish indicated that the remaining lymphocytes were no longer capable of responding to mitogenic stimuli. 4. This suppression of mitogenic stimuli was not seen when peripheral blood leucocytes were cultured in vitro with physiologic doses of cortisol. 5. This latter observation suggests that the cortisol alone was probably not directly responsible for the loss of responsiveness but possibly acted in vivo as an initiator of other events that eventually resulted in the observed immunosuppression.
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