Dual inversion recovery ultrashort echo time (DIR-UTE) imaging and quantification of the zone of calcified cartilage (ZCC).
Dual inversion recovery ultrashort echo time (DIR-UTE) imaging and quantification of the zone of calcified cartilage (ZCC).
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DOI：
10.1016/j.joca.2012.09.009
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发表时间：
2013-01
影响因子：
7
通讯作者：
Chung, C. B.
中科院分区：
文献类型：
--
作者：
Du, J.;Carl, M.;Bae, W. C.;Statum, S.;Chang, E. Y.;Bydder, G. M.;Chung, C. B.
开发超短回波时间 (UTE) 磁共振成像 (MRI) 技术，对钙化软骨 (ZCC) 区域进行成像，并量化其 T2*、T1 和 T1ρ。在这项可行性研究中，开发了双反转恢复超短回波时间 (DIR-UTE) 序列，用于 ZCC 的高对比度成像。 ZCC 的 T2* 是通过在逐渐增加的 TE 下采集 DIR-UTE 来测量的。 ZCC 的 T1 是通过在逐渐增加的饱和恢复时间下采集饱和恢复 UTE 来测量的。 ZCC 的 T1ρ 是通过自旋锁定准备的 DIR-UTE 采集以逐渐增加的自旋锁定时间来测量的。使用临床 3T 扫描仪在体模和六块尸体髌骨上证明了定性和定量 DIR-UTE 技术的可行性。平均而言，ZCC 的短 T2* 范围为 1.0 至 3.3 ms（平均值 ± 标准偏差 = 2.0 ± 1.2 ms），短 T1 范围为 256 至 389 ms（平均值 ± 标准偏差 = 305 ± 45 ms），以及短 T1ρ 范围为 2.2 至 4.6 ms（平均值 ± 标准偏差 = 3.6 ± 1.2 ms）。基于 UTE MR 的技术已开发用于 ZCC 的高分辨率成像及其 T2*、T1 和 T1ρ 弛豫时间的定量评估，从而对钙化软骨区域和骨软骨界面处的胶原蛋白取向和蛋白多糖含量进行无创评估。这些测量可能有助于 ZCC 的非侵入性评估，包括了解该组织成分在骨关节炎中的参与情况。
To develop ultrashort echo time (UTE) magnetic resonance imaging (MRI) techniques to image the zone of calcified cartilage (ZCC), and quantify its T2*, T1 and T1ρ. In this feasibility study a dual inversion recovery ultrashort echo time (DIR-UTE) sequence was developed for high contrast imaging of the ZCC. T2* of the ZCC was measured with DIR-UTE acquisitions at progressively increasing TEs. T1 of the ZCC was measured with saturation recovery UTE acquisitions at progressively increasing saturation recovery times. T1ρ of the ZCC was measured with spin-locking prepared DIR-UTE acquisitions at progressively increasing spin-locking times. The feasibility of the qualitative and quantitative DIR-UTE techniques was demonstrated on phantoms and in six cadaveric patellae using a clinical 3T scanner. On average the ZCC has a short T2* ranging from 1.0 to 3.3 ms (mean ± standard deviation = 2.0 ± 1.2 ms), a short T1 ranging from 256 to 389 ms (mean ± standard deviation = 305 ± 45 ms), and a short T1ρ ranging from 2.2 to 4.6 ms (mean ± standard deviation = 3.6 ± 1.2 ms). UTE MR based techniques have been developed for high resolution imaging of the ZCC and quantitative evaluation of its T2*, T1 and T1ρ relaxation times, providing noninvasive assessment of collagen orientation and proteoglycan content at the zone of calcified cartilage and the bone cartilage interface. These measurements may be useful for non-invasive assessment of the ZCC, including understanding the involvement of this tissue component in osteoarthritis.
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影响因子：
3.3
作者：
Du J;Takahashi AM;Bae WC;Chung CB;Bydder GM
通讯作者：
Bydder GM
DOI：
10.1302/0301-620x.65b1.6337169
发表时间：
1983-01-01
影响因子：
--
作者：
BULLOUGH, PG;JAGANNATH, A
通讯作者：
JAGANNATH, A
影响因子：
5
作者：
Gold, GE;Han, E;Beaulieu, C
通讯作者：
Beaulieu, C
影响因子：
3.3
作者：
Larson, Peder E. Z.;Gurney, Paul T.;Nishimura, Dwight G.
通讯作者：
Nishimura, Dwight G.
影响因子：
19.7
作者：
Bae, Won C.;Dwek, Jerry R.;Chung, Christine B.
通讯作者：
Chung, Christine B.