Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.
Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.
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六种单核苷酸多态性与中国人群妊娠期糖尿病的关联
DOI：
10.1371/journal.pone.0026953
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Wang Y;Nie M;Li W;Ping F;Hu Y;Ma L;Gao J;Liu J
背景：探讨中国孕妇2型糖尿病易感基因是否也与妊娠期糖尿病相关。方法/主要发现在这项研究中，招募了1764名无血缘关系的孕妇，其中725名患有妊娠期糖尿病，1039名作为对照。采用TaqMan等位基因鉴别法对CDKAL1中的rs7754840、SRR中的rs391300、CDKN2A/2B中的rs2383208、IGF2BP2中的rs4402960、MTNR1B中的rs10830963、GCK中的rs4607517进行了基因分型。分析各SNP在妊娠期糖尿病患者和对照组中的基因和等位基因分布，以及等位基因联合作用对GDM发病风险的影响。结果发现，rs4402960、rs2383208和rs391300与妊娠期糖尿病有统计学关联(OR = 1.207，95%CI = 1.029-1.417，p = 0.021；OR = 1.242，95%CI = 1.077-1.432，p = 0.003；OR = 1.202，95%CI = 1.020-1.416，P = 0.028)。此外，rs391300的隐性模型的影响更大(OR = 1.820，95%CI = 1.226-2.701，p = 0.003)。同时，这3个基因座的联合作用表明，多个等位基因对妊娠期糖尿病的风险具有加性效应，每个等位基因的OR值为1.196(p = 1.08×10−4)。我们还发现rs2383208(b = −0.085，p = 0.003)、rs4402960(b = −0.057，p = 0.046)和rs10830963(b = −0.096，p = 0.001)等位基因与HOMA-B相关，而rs7754840与糖耐量减低相关(b = −0.080，p = 0.007)。结论中国孕妇2型糖尿病的几个危险等位基因与妊娠期糖尿病相关。这些SNP对GDM的影响可能是通过β细胞功能受损而实现的，而这些危险基因对GDM的发病起到了额外的作用。
Background To investigate whether the candidate genes that confer susceptibility to type 2 diabetes mellitus are also correlated with gestational diabetes mellitus (GDM) in pregnant Chinese women. Methodology/Principal Findings In this study, 1764 unrelated pregnant women were recruited, of which 725 women had GDM and 1039 served as controls. Six single nucleotide polymorphisms (rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK) were genotyped using TaqMan allelic discrimination assays. The genotype and allele distributions of each SNP between the GDM cases and controls and the combined effects of alleles for the risk of developing GDM were analyzed. We found that the rs4402960, rs2383208 and rs391300 were statistically associated with GDM (OR = 1.207, 95%CI = 1.029–1.417, p = 0.021; OR = 1.242, 95%CI = 1.077–1.432, p = 0.003; OR = 1.202, 95%CI = 1.020–1.416, P = 0.028, respectively). In addition, the effect was greater under a recessive model in rs391300 (OR = 1.820, 95%CI = 1.226–2.701, p = 0.003). Meanwhile, the joint effect of these three loci indicated an additive effect of multiple alleles on the risk of developing GDM with an OR of 1.196 per allele (p = 1.08×10−4). We also found that the risk alleles of rs2383208 (b = −0.085, p = 0.003), rs4402960 (b = −0.057, p = 0.046) and rs10830963 (b = −0.096, p = 0.001) were associated with HOMA-B, while rs7754840 was associated with decrease in insulin AUC during a 100 g OGTT given at the time of GDM diagnosis (b = −0.080, p = 0.007). Conclusions/Significance Several risk alleles of type 2 diabetes were associated with GDM in pregnant Chinese women. The effects of these SNPs on GDM might be through the impairment of beta cell function and these risk loci contributed additively to the disease.
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影响因子：
7.7
作者：
Lango H;UK Type 2 Diabetes Genetics Consortium;Palmer CN;Morris AD;Zeggini E;Hattersley AT;McCarthy MI;Frayling TM;Weedon MN
通讯作者：
Weedon MN
影响因子：
8.2
作者：
Below, J. E.;Gamazon, E. R.;Morrison, J. V.;Konkashbaev, A.;Pluzhnikov, A.;McKeigue, P. M.;Parra, E. J.;Elbein, S. C.;Hallman, D. M.;Nicolae, D. L.;Bell, G. I.;Cruz, M.;Cox, N. J.;Hanis, C. L.
通讯作者：
Hanis, C. L.
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影响因子：
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作者：
Lin, Ying;Li, Pengqiu;Yang, Zhenglin
通讯作者：
Yang, Zhenglin
影响因子：
8.2
作者：
Cho, Y. M.;Kim, T. H.;Jang, H. C.
通讯作者：
Jang, H. C.
影响因子：
5.8
作者：
Lauenborg, Jeannet;Grarup, Niels;Hansen, Torben
通讯作者：
Hansen, Torben