Prognoses and long-term outcomes of nasopharyngeal carcinoma in Han and Uyghur patients treated with intensity-modulated radiotherapy in the Xinjiang Autonomous Region of China.
Prognoses and long-term outcomes of nasopharyngeal carcinoma in Han and Uyghur patients treated with intensity-modulated radiotherapy in the Xinjiang Autonomous Region of China.
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中国新疆自治区汉族和维吾尔族调强放射治疗鼻咽癌患者的预后和长期结果
DOI：
10.1371/journal.pone.0111145
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
Wang R;Tan Y;Wang X;Ma L;Wang D;Hu Y;Qin Y;Liu K;Chang C;Yu J
目的 本研究的目的是调查中国新疆地区汉族和维吾尔族患者接受调强放疗 (IMRT) 治疗鼻咽癌 (NPC) 的长期结果和预后因素。材料与方法 2005年至2008年新疆医科大学附属肿瘤医院121例汉族和60例维吾尔族初诊鼻咽癌无远处转移患者接受IMRT治疗。采用Kaplan-Meier法估计生存率，并采用时序检验评价生存差异。结果 汉族和维吾尔族患者的5年总生存率（OS）、无病生存率（DFS）、局部控制率（LC）、区域控制率（RC）和远处无转移生存率（DMFS）分别为81.9% vs 77.6%（P = 0.297）、72.1% vs 65.6%（P = 0.493）。 88.3% 对比 分别为 86.5%（P = 0.759）、95.0% vs 94.6%（P = 0.929）和 79.1% vs 75.2%（P = 0.613）。多变量 Cox 比例风险回归确定了汉族患者的以下独立预后因素：OS 分期 (P = 0.007) 和年龄 (P = 0.028)，DFS 年龄 (P = 0.028)。汉族和维吾尔族>60岁组患者的OS存在显着差异（P = 0.036）。在维吾尔族患者中，独立预后因素是OS年龄（P = 0.033）、N分期（P = 0.037）和DFS年龄（P = 0.021）。此外，维吾尔族患者比汉族患者患粘膜炎和皮炎的可能性更低。结论 汉族和维吾尔族鼻咽癌患者在年龄、吸烟史、N分期等方面差异有统计学意义。中国新疆这两个民族的 IMRT 总体治疗结果没有显着差异。
Objectives The objective of this study was to investigate the long-term outcomes and prognostic factors for nasopharyngeal carcinoma (NPC) in Han and Uyghur patients treated with intensity-modulated radiotherapy (IMRT) in the Xinjiang region of China. Materials and Methods One hundred twenty-one Han and 60 Uyghur patients with newly diagnosed NPC without distant metastasis received IMRT at the Affiliated Tumor Hospital of Xinjiang Medical University between 2005 and 2008. The Kaplan-Meier method was used to estimate survival rates, and the log-rank test was used to evaluate differences in survival. Results Comparing Han and Uyghur patients, the 5-year overall survival (OS), disease-free survival (DFS), local control (LC), regional control (RC), and distant metastasis-free survival (DMFS) rates were 81.9% vs 77.6% (P = 0.297), 72.1% vs 65.6% (P = 0.493), 88.3% vs 86.5% (P = 0.759), 95.0% vs 94.6% (P = 0.929), and 79.1% vs 75.2% (P = 0.613), respectively. Multivariate Cox proportional hazards regression identified the following independent prognostic factors in Han patients: N stage (P = 0.007) and age (P = 0.028) for OS, and age (P = 0.028) for DFS. OS differed significantly between Han and Uyghur patients >60 years old group (P = 0.036). Among Uyghur patients, the independent prognostic factors were age for OS (P = 0.033), as well as N stage (P = 0.037) and age (P = 0.021) for DFS. Additionally, Uyghur patients were less likely to experience mucositis and dermatitis than Han patients. Conclusion Han and Uyghur patients with NPC had statistically significant differences in age, smoking history, and N staging. There was no significant difference in overall treatment outcomes with IMRT between these 2 ethnic populations in Xinjiang, China.
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DOI：
10.1186/1748-717x-7-2
发表时间：
2012-01-10
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Wang J;Shi M;Hsia Y;Luo S;Zhao L;Xu M;Xiao F;Fu X;Li J;Zhou B;Long X
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调强放疗联合化疗对局部晚期鼻咽癌患者的生存获益
影响因子：
3.7
作者：
Ji X;Xie C;Hu D;Fan X;Zhou Y;Zheng Y
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Zheng Y
影响因子：
6.2
作者：
Kwong, DLW;Pow, EHN;Au, GKH
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Au, GKH
DOI：
10.1016/j.ijrobp.2004.11.002
发表时间：
2005-07-01
影响因子：
7
作者：
Yeh, SA;Tang, Y;Huang, EY
通讯作者：
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Su SF;Han F;Zhao C;Huang Y;Chen CY;Xiao WW;Li JX;Lu TX
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