A genetically informed Registered Report on adverse childhood experiences and mental health.
A genetically informed Registered Report on adverse childhood experiences and mental health.
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DOI：
10.1038/s41562-022-01482-9
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发表时间：
2023-03
影响因子：
29.9
通讯作者：
Pingault JB
中科院分区：
文献类型：
--
作者：
Baldwin JR;Sallis HM;Schoeler T;Taylor MJ;Kwong ASF;Tielbeek JJ;Barkhuizen W;Warrier V;Howe LD;Danese A;McCrory E;Rijsdijk F;Larsson H;Lundström S;Karlsson R;Lichtenstein P;Munafò M;Pingault JB
经历过逆境的儿童出现心理健康问题的风险更高。然而，不良童年经历(ACE)导致精神健康问题的程度尚不清楚，因为以前的关联可能部分反映了遗传混淆。在这份注册的报告中，我们使用了来自英国和美国的11,407名儿童的DNA来调查基因与环境的相关性以及ACE与心理健康之间的遗传混淆。在基因-环境相关性方面，精神健康问题多基因得分较高的儿童患A级的几率略有增加。关于遗传混淆，暴露于ACEs的儿童精神健康问题的风险增加至少部分是由于先前存在的遗传风险。然而，一些ACEs(例如，童年虐待、父母精神疾病)仍然与独立于遗传混淆的精神健康问题有关。这些发现表明，针对暴露于ACE的儿童可遗传的精神脆弱性进行干预可能有助于降低他们出现心理健康问题的风险。
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the UK and USA to investigate gene-environment correlations and genetic confounding of the associations between ACEs and mental health. Regarding gene-environment correlations, children with higher polygenic scores for mental health problems had a small increase in odds for ACEs. Regarding genetic confounding, elevated risk of mental health problems in children exposed to ACEs was at least partially due to pre-existing genetic risk. However, some ACEs (e.g., childhood maltreatment, parental mental illness) remained associated with mental health problems independent of genetic confounding. These findings suggest that interventions addressing heritable psychiatric vulnerabilities in children exposed to ACEs may help to reduce their risk of mental health problems.
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影响因子：
5.4
作者：
Anderson JJ;Kruszka B;Delaney JA;He K;Burke GL;Alonso A;Bild DE;Budoff M;Michos ED
通讯作者：
Michos ED
影响因子：
26.1
作者：
Baldwin JR;Caspi A;Meehan AJ;Ambler A;Arseneault L;Fisher HL;Harrington H;Matthews T;Odgers CL;Poulton R;Ramrakha S;Moffitt TE;Danese A
通讯作者：
Danese A
影响因子：
4.8
作者：
Cecil, Charlotte A. M.;Viding, Essi;McCrory, Eamon J.
通讯作者：
McCrory, Eamon J.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.9
作者：
Bornovalova MA;Cummings JR;Hunt E;Blazei R;Malone S;Iacono WG
通讯作者：
Iacono WG