Assessing early erythrolysis and the relationship to perihematomal iron overload and white matter survival in human intracerebral hemorrhage.
Assessing early erythrolysis and the relationship to perihematomal iron overload and white matter survival in human intracerebral hemorrhage.
复制标题
DOI：
10.1111/cns.13693
复制
发表时间：
2021-10
影响因子：
5.5
通讯作者：
Chaudhary N
中科院分区：
文献类型：
--
作者：
Novakovic N;Wilseck ZM;Chenevert TL;Xi G;Keep RF;Pandey AS;Chaudhary N
血肿内溶解红细胞释放的铁在脑出血（ICH）相关神经毒性中起作用。本研究利用磁共振成像（MRI）检查红细胞溶解的时间过程、程度及其与血肿周围铁积聚和白色物质丢失的相关性。使用具有特定程度红细胞溶解的猪血液模型，检查使用T2* MRI评估红细胞溶解比例的可行性。15例前瞻性入组的ICH患者在第1-3、14和30天（分别称为早期、亚急性和晚期）接受MRI（3 T）。在T2*、1/T2* 和各向异性分数（FA）图上进行测量。猪血液模型显示1/T2* 信号与红细胞溶解百分比之间的线性关系。患者的MRI显示，在ICH后的早期和亚急性期之间，血肿内的红细胞溶解增加，几乎在第14天完成。虽然血肿周围铁超载（IO）与第14天和第30天的红细胞溶解程度和血肿体积相关，但血肿周围白色物质（WM）丢失仅在第14天与两者显著相关。MRI可以可靠地评估ICH后随时间溶解的血肿部分。血肿周围IO和WM丢失与ICH后早期和亚急性期的红细胞溶解程度和血肿体积相关。第一项量化人类脑内血肿内红细胞溶解并与血肿周围铁过载和白色损伤相关的研究。
Iron released from lysed red blood cells within the hematoma plays a role in intracerebral hemorrhage (ICH)‐related neurotoxicity. This study utilizes magnetic resonance imaging (MRI) to examine the time course, extent of erythrolysis, and its correlation with perihematomal iron accumulation and white matter loss. The feasibility of assessing proportional erythrolysis using T2* MRI was examined using pig blood phantoms with specified degrees of erythrolysis. Fifteen prospectively enrolled ICH patients had MRIs (3‐Tesla) at days 1–3, 14, and 30 (termed early, subacute, and late periods, respectively). Measurement was performed on T2*, 1/T2*, and fractional anisotropy (FA) maps. Pig blood phantoms showed a linear relationship between 1/T2* signal and percent erythrolysis. MRI on patients showed an increase in erythrolysis within the hematoma between the early and subacute phases after ICH, almost completing by day 14. Although perihematomal iron overload (IO) correlated with the erythrolysis extent and hematoma volume at days 14 and 30, perihematomal white matter (WM) loss significantly correlated with both, only at day 14. MRI may reliably assess the portion of the hematoma that lyses over time after ICH. Perihematomal IO and WM loss correlate with both the erythrolysis extent and hematoma volume in the early and subacute periods following ICH. First study to quantify erythrolysis within hematoma in human intracerebral and correlate with perihematomal iron overload and white matter injury.
登录
查看更多内容
影响因子：
6.9
作者：
Wei J;Wang M;Jing C;Keep RF;Hua Y;Xi G
通讯作者：
Xi G
影响因子：
8.3
作者：
Hemphill, JC;Bonovich, DC;Johnston, SC
通讯作者：
Johnston, SC
影响因子：
168.9
作者：
Hanley, Daniel F.;Thompson, Richard E.;Awad, Issam A.
通讯作者：
Awad, Issam A.
影响因子：
8.3
作者：
Wang, Ming;Hua, Ya;Xi, Guohua
通讯作者：
Xi, Guohua
影响因子：
6.9
作者：
Dang G;Yang Y;Wu G;Hua Y;Keep RF;Xi G
通讯作者：
Xi G