Management of uveitis-related choroidal neovascularization: from the pathogenesis to the therapy.
Management of uveitis-related choroidal neovascularization: from the pathogenesis to the therapy.
复制标题
与葡萄膜炎相关的脉络膜新血管形成：从发病机理到治疗。
DOI：
10.1155/2014/450428
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发表时间：
2014
影响因子：
1.9
通讯作者：
Iannetti L
中科院分区：
文献类型：
--
作者：
D'Ambrosio E;Tortorella P;Iannetti L
炎性脉络膜新生血管是葡萄膜炎的一种严重但不常见的并发症，在后葡萄膜炎如点状内脉络膜病变、多灶性脉络膜炎、蜿蜒性脉络膜炎和Vogt-Koyanagi-Harada综合征中更常见。其发病机制与湿性年龄相关性黄斑变性相似：缺氧，血管内皮生长因子，基质细胞衍生因子1-α和其他介质的释放似乎参与了葡萄膜炎相关的脉络膜新生血管形成。本文就炎症性脉络膜新生血管的发病机制作一综述。此外，我们报告了过去十年中关于葡萄膜炎继发脉络膜新生血管治疗的单一研究的成功率：光动力学治疗，玻璃体内贝伐单抗和玻璃体内雷珠单抗，以及类固醇和免疫抑制剂治疗。因此，提出了治疗方法的标准化。
Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization. A review on the factors implicated so far in the pathogenesis of inflammatory choroidal neovascularization was performed. Also we reported the success rate of single studies concerning the therapies of choroidal neovascularization secondary to uveitis during the last decade: photodynamic therapy, intravitreal bevacizumab, and intravitreal ranibizumab, besides steroidal and immunosuppressive therapy. Hereby a standardization of the therapeutic approach is proposed.
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影响因子：
15.9
作者：
Butler, JM;Guthrie, SM;Scott, EW
通讯作者：
Scott, EW
DOI：
10.1083/jcb.200409115
发表时间：
2005-05-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lee S;Jilani SM;Nikolova GV;Carpizo D;Iruela-Arispe ML
通讯作者：
Iruela-Arispe ML
影响因子：
3.4
作者：
Julian, Karina;Terrada, Celine;Bodaghi, Bahram
通讯作者：
Bodaghi, Bahram
影响因子：
--
作者：
Dees, C;Arnold, JJ;Dick, AD
通讯作者：
Dick, AD
影响因子：
2.6
作者：
Carneiro, Angela M.;Silva, Rufino M.;Falcao-Reis, Fernando M.
通讯作者：
Falcao-Reis, Fernando M.