Extensively drug resistant tuberculosis in a high income country: a report of four unrelated cases.
Extensively drug resistant tuberculosis in a high income country: a report of four unrelated cases.
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DOI：
10.1186/1471-2334-8-60
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发表时间：
2008-05-02
影响因子：
3.7
通讯作者：
Naumann, Ludmila
中科院分区：
文献类型：
--
作者：
Blaas, Stefan H.;Muetterlein, Ralf;Weig, Johannes;Neher, Albert;Salzberger, Bernd;Lehn, Norbert;Naumann, Ludmila
结核分枝杆菌（M.结核病（XDR）仍然是对公共卫生的主要威胁，最近关于南非感染广泛耐药（XDR）菌株的患者的临床过程的报告加强了这一点。关于工业化国家XDR结核病患者的临床病程信息很少。我们评价了所有M.自1997年以来，在我们的机构进行药物敏感性测试的结核病，对多种和广泛的耐药性。对符合最近修订的XDR结核标准的菌株感染患者的临床病程进行了分析。四个XDR M。鉴定了结核分离株。所有患者都是从俄罗斯、格鲁吉亚和前南斯拉夫移民到德国的，没有人感染人类免疫缺陷病毒。所有患者的结核病治疗时间为5.5至15年，XDR结核病治疗时间为1.9至2.5年。他们在德国接受了11个月、4.5年和两次6年的住院治疗。不遵守规定是所有四名患者的一个重要因素，三名患者不得不在德国唯一的封闭式结核病治疗设施接受治疗。1例XDR肺结核死亡，1例末次接触时仍为开放性肺结核，2例治愈。我们地区治疗广泛耐药结核病例已有数年。即使在高收入环境中，XDR结核病也对生活质量、结果和总成本产生巨大影响。必须采取并保持一切合理的努力来防止XDR结核病的传播。
Multi drug resistance of Mycobacterium tuberculosis (M. tuberculosis) remains a major threat to public health, reinforced by recent reports about the clinical course of patients infected with extensively drug resistant (XDR) strains in South Africa. There is little information about the clinical course of XDR tuberculosis patients in industrialised countries. We evaluated all isolates of M. tuberculosis, in which drug susceptibility testing was performed at our institution since 1997, for multi and extensive drug resistance. Clinical courses of patients infected by strains fulfilling the recently revised criteria for XDR tuberculosis were analysed. Four XDR M. tuberculosis isolates were identified. All patients had immigrated to Germany from Russia, Georgia, and former Yugoslavia and none were infected by the human immunodeficiency virus. All patients where treated for tuberculosis for 5.5 to 15 years and for XDR tuberculosis for 1.9 to 2.5 years. They received inhospital treatment in Germany for 11 months, 4.5 years and twice for 6 years. Non-compliance was an important factor in all four patients, three patients had to be treated in Germanys only locked facility for tuberculosis treatment. One patient with XDR tuberculosis died, one patient had still open pulmonary tuberculosis at last contact and 2 patients were cured. Cases of XDR tuberculosis have been treated in our region for several years. Even in a high income setting, XDR tuberculosis has a tremendous impact on quality of live, outcome and the total cost. All reasonable efforts to prevent the spread of XDR tuberculosis must be made and maintained.
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影响因子：
9.4
作者：
Ådjers-Koskela, K;Katila, ML
通讯作者：
Katila, ML
DOI：
10.1089/mdr.2005.11.137
发表时间：
2005-06-01
期刊：
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE
影响因子：
--
作者：
Karahan, ZC;Akar, N
通讯作者：
Akar, N
DOI：
10.1164/rccm.200503-449oc
发表时间：
2005-09-01
影响因子：
24.7
作者：
van Rie, A;Victor, TC;Warren, RM
通讯作者：
Warren, RM
影响因子：
9.4
作者：
Heep, M;Brandstätter, B;Niemann, S
通讯作者：
Niemann, S
影响因子：
168.9
作者：
Gandhi, Neel R.;Moll, Anthony;Friedland, Gerald
通讯作者：
Friedland, Gerald