The Gut Microbiota: How Does It Influence the Development and Progression of Liver Diseases.
The Gut Microbiota: How Does It Influence the Development and Progression of Liver Diseases.
复制标题
肠道微生物群：它如何影响肝脏疾病的发生和发展？
DOI：
10.3390/biomedicines8110501
复制
发表时间：
2020-11-16
期刊：
影响因子：
4.7
通讯作者：
Kim H
中科院分区：
文献类型：
--
作者：
Kanmani P;Suganya K;Kim H
肠道-肝脏轴在维持健康肝脏和肝脏疾病的发病机制中起着重要作用，其中肠道微生物群是这种关系的主要决定因素。肠道细菌衍生的代谢产物和细胞组分是影响肝脏功能和调节肝脏疾病病理的关键分子。越来越多的证据表明，肠道微生物群产生无数的分子，包括脂多糖、脂磷壁酸、肽聚糖和DNA，以及短链脂肪酸、胆汁酸、三甲胺和吲哚衍生物。这些成分转移到肝脏通过与肝脏免疫细胞相互作用发挥有益或致病作用。这是一种双向的关系。因此，肠道和肝脏之间的串扰的存在及其对宿主健康和疾病的影响对于疾病的病因学和治疗至关重要。已经提出了几种肝脏疾病的发病机制，但肠源性成分对肝脏发病机制的致病作用背后的机制仍然是难以捉摸和不可理解的。本文综述了肠道菌群及其组分在肝脏疾病进展中的作用，以及肝脏疾病如何间接影响肠道功能和诱导肠道炎症的研究进展。此外，本文强调了目前用于恢复肠道微生物群组成和改善宿主健康的治疗和预防策略。
The gut–liver axis plays important roles in both the maintenance of a healthy liver and the pathogenesis of liver diseases, where the gut microbiota acts as a major determinant of this relationship. Gut bacteria-derived metabolites and cellular components are key molecules that affect the function of the liver and modulate the pathology of liver diseases. Accumulating evidence showed that gut microbiota produces a myriad of molecules, including lipopolysaccharide, lipoteichoic acid, peptidoglycan, and DNA, as well as short-chain fatty acids, bile acids, trimethylamine, and indole derivatives. The translocation of these components to the liver exerts beneficial or pathogenic effects by interacting with liver immune cells. This is a bidirectional relationship. Therefore, the existence of crosstalk between the gut and liver and its implications on host health and diseases are essential for the etiology and treatment of diseases. Several mechanisms have been proposed for the pathogenesis of liver diseases, but still, the mechanisms behind the pathogenic role of gut-derived components on liver pathogenesis remain elusive and not understandable. This review discusses the current progress on the gut microbiota and its components in terms of the progression of liver diseases, and in turn, how liver diseases indirectly affect the intestinal function and induce intestinal inflammation. Moreover, this paper highlights the current therapeutic and preventive strategies used to restore the gut microbiota composition and improve host health.
登录
查看更多内容
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
4.8
作者：
Bala, Shashi;Marcos, Miguel;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
DOI：
10.1152/ajpgi.00163.2009
发表时间：
2011-03-01
影响因子：
4.5
作者：
Csak, Timea;Velayudham, Arumugam;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
影响因子：
3.5
作者：
Carazo, Alejandro;Hyrsova, Lucie;Pavek, Petr
通讯作者：
Pavek, Petr
影响因子：
8.9
作者：
Cassard AM;Ciocan D
通讯作者：
Ciocan D