Performance of self-reported occupational exposure compared to a job-exposure matrix approach in asthma and chronic rhinitis.
Performance of self-reported occupational exposure compared to a job-exposure matrix approach in asthma and chronic rhinitis.
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DOI：
10.1136/oem.2008.040022
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发表时间：
2009-03
影响因子：
4.9
通讯作者：
Blanc PD
中科院分区：
文献类型：
--
作者：
Quinlan PJ;Earnest G;Eisner MD;Yelin EH;Katz PP;Balmes JR;Blanc PD
自报暴露于蒸气、气体、粉尘或烟雾（VGDF）已被广泛用作慢性肺部疾病流行病学研究中的职业暴露指标。我们的目标是表征VGDF的重复性，系统误分类，敏感性和特异性对暴露可能性的工作暴露矩阵（JEM）的性能。我们分析了两次访谈的数据，间隔24个月，在成人哮喘和慢性鼻炎。使用不同的工作作为分析单位，我们测试了一个单一的响应项目（暴露于VGDF）对分配使用工作暴露矩阵（JEM）。我们进一步分析了VGDF和JEM在一个子集的199名受试者谁报告了相同的工作，在两次面试中，使用逻辑回归分析，以测试与VGDF的不一致和不一致与JEM的因素。在研究的348名受试者从事的436个不同工作中，193人（44%）报告了VGDF; JEM将中度至高度暴露可能性分配给120人（28%）。VGDF对JEM的敏感性和特异性分别为71%和66%。在199名在两次访谈中从事相同工作的受试者中，32%的人的VGDF状态不一致（kappa= 0.35）。与单纯哮喘相比，慢性鼻炎伴发哮喘的患者更可能有与JEM不一致的VGDF报告（OR 3.6 [95% CI 1.4-9.0]; p=0.01）。在JEM分类为低暴露的工作中，鼻炎也与报告的VGDF相关（OR 3.9 [95% CI 1.6-9.4]; p=0.003）。以正义与平等运动为基准，VGDF项目的敏感度为中等。该方法为职业暴露风险的流行病学研究提供了一种有效的评价方法。
Self-reported exposure to vapors, gas, dust, or fumes (VGDF) has been widely used as an occupational exposure metric in epidemiologic studies of chronic lung diseases. Our objective was to characterize the performance of VGDF for repeatability, systematic misclassification, and sensitivity and specificity against exposure likelihood by a job exposure matrix (JEM). We analyzed data from two interviews, 24 months apart, among adults with asthma and chronic rhinitis. Using distinct job as the unit of analysis, we tested a single response item (exposure to VGDF) against assignment using a job exposure matrix (JEM). We further analyzed VGDF and JEM among a subset of 199 subjects who reported the same job at both interviews, using logistic regression analysis to test factors associated with VGDF inconsistency and discordance with JEM. For 436 distinct jobs held by 348 subjects studied, VGDF was reported for 193 (44%); moderate to high exposure likelihood by JEM was assigned to 120 (28%). The sensitivity and specificity of VGDF against JEM was 71% and 66%, respectively. Among 199 subjects with the same job at both interviews, 32% had discordant VGDF status (kappa= 0.35). Those with chronic rhinitis without concomitant asthma compared to asthma alone were more likely to have a VGDF report that was discordant with the JEM (OR 3.6 [95% CI 1.4–9.0]; p=0.01). Rhinitis was also associated with reported VGDF in a job classified by JEM as low exposure (OR 3.9 [95% CI 1.6–9.4]; p=0.003). The VGDF item is moderately sensitive measured against JEM as a benchmark. The measure is a useful assessment method for epidemiological studies of occupational exposure risk.
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影响因子：
9.6
作者：
Blanc, PD;Cisternas, M;Yelin, EH
通讯作者：
Yelin, EH
影响因子：
7.7
作者：
HEEDERIK, D;POUWELS, H;KROMHOUT, D
通讯作者：
KROMHOUT, D
影响因子：
7.2
作者：
Blanc, PD;Trupin, L;Yelin, EH
通讯作者：
Yelin, EH
影响因子：
4.9
作者：
Blanc, PD;Eisner, MD;Balmes, JR
通讯作者：
Balmes, JR
DOI：
10.1164/ajrccm.160.6.9901033
发表时间：
1999-12-01
影响因子：
24.7
作者：
Blanc, PD;Ellbjär, S;Torén, K
通讯作者：
Torén, K