Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques.
Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques.
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DOI：
10.1038/jid.2010.166
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发表时间：
2010-11
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窄带紫外线B辐射(NB-UVB)疗法为银屑病提供了一种成熟的治疗方式。然而，尽管这种治疗形式被普遍使用，但NB-UVB的作用机制尚不清楚。我们对14例中到重度银屑病患者进行了6周的仔细滴定和监测的NB-UVB治疗。根据病变斑块的组织学改善和正常化程度，将病变斑块分为正常斑块(n=8)和无反应斑块(n=6)。我们用免疫组织化学和实时定量聚合酶链式反应鉴定了皮损髓系树突状细胞(DC)和T细胞及其炎症介质。NB-UVB可抑制正常斑块中IL-23/IL-17通路的多个参数，但不能抑制无反应斑块中IL-23/IL-17通路的多个参数。NB-UVB可减少CD11c+DC的数量，尤其是CD1c−CD11c+“炎症性”DC及其产物IL-20、iNOS、IL-12/23p40和IL-23p19。此外，有效的NB-UVB可抑制IL-17和IL-22mRNA的表达，而IL-17和IL-22的表达与病变的消退密切相关。因此，除了已知的抑制干扰素-γ产生的作用外，NB-UVB放射治疗还可以靶向IL-17途径来化解银屑病炎症。
Narrow-band ultraviolet B radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB is not well understood. We studied a group of 14 patients with moderate-to-severe psoriasis treated with carefully titrated and monitored NB-UVB for 6 weeks. Lesional plaques were classified as normalized (n=8) or non-responsive (n=6) based on their histological improvement and normalization. We characterized lesional myeloid dendritic cells (DCs) and T cells and their inflammatory mediators using immunohistochemistry and real-time PCR. NB-UVB suppressed multiple parameters of the IL-23/IL-17 pathway in normalized plaques, but not in non-responsive plaques. NB-UVB decreased numbers of CD11c+ DCs, specifically CD1c−CD11c+ “inflammatory” DCs, and their products, IL-20, iNOS, IL-12/23p40 and IL-23p19. Furthermore, effective NB-UVB suppressed IL-17 and IL-22 mRNA, which strongly correlated with lesion resolution. Therefore, in addition to its known role in suppressing IFN-γ production, NB-UVB radiation therapy can also target the IL-17 pathway to resolve psoriatic inflammation.
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DOI：
10.1038/jid.2009.65
发表时间：
2009-09
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
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影响因子：
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作者：
Lowes, Michelle A.;Turton, James A.;Barnetson, Ross StC
通讯作者：
Barnetson, Ross StC
影响因子：
6.5
作者：
NOONAN, FP;DEFABO, EC;MORRISON, H
通讯作者：
MORRISON, H
影响因子：
10.3
作者：
MURPHY, GM;NORRIS, PG;HAWK, JLM
通讯作者：
HAWK, JLM
DOI：
10.1073/pnas.0409569102
发表时间：
2005-02-08
影响因子：
11.1
作者：
Chamian, F;Lowes, MA;Krueger, JG
通讯作者：
Krueger, JG