Inflammasome, Inflammation, and Tissue Homeostasis.
Inflammasome, Inflammation, and Tissue Homeostasis.
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DOI：
10.1016/j.molmed.2018.01.004
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发表时间：
2018-03
影响因子：
13.6
通讯作者：
Chan FK
中科院分区：
文献类型：
--
作者：
Rathinam VAK;Chan FK
Organismal fitness demands proper response to neutralize the threat from infection or injury. At the mammalian intestinal epithelium barrier, the inflammasome coordinates an elaborate tissue repair response marked by the induction of anti-microbial peptides, wound-healing cytokines, and reparative proliferation of epithelial stem cells. The inflammasome in myeloid and intestinal epithelial compartments exerts these effects in part, through maintenance of a healthy microbiota. Disease-associated mutations and elevated expression of certain inflammasome sensors have been identified. In many cases, inhibition of inflammasome activity has dramatic effects on disease outcome in mouse models of experimental colitis. Here, we discuss recent studies on the role of distinct inflammasome sensors in intestinal homeostasis and how this knowledge may be translated into a therapeutic setting.
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