Unknown primary malignant small round cell tumor masquerading as acute leukemia.
Unknown primary malignant small round cell tumor masquerading as acute leukemia.
复制标题
未知的原发性恶性小圆细胞肿瘤，伪装成急性白血病。
DOI：
10.1111/ped.15158
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
[Hiroki Iwaizako,Takuro Nishikawa,Ikumi Kitazono,Akihide Tanimoto,Yasuhiro Okamoto]
中科院分区：
文献类型：
--
作者：
Hijikata M;Morioka I;Okahashi A;Nagano N;Kawakami K;Komatsu A;Kawana K;Ohyama S;Fujioka K;Tanimura K;Deguchi M;Sasai M;Yamamoto M;Yamada H.;[Hiroki Iwaizako,Takuro Nishikawa,Ikumi Kitazono,Akihide Tanimoto,Yasuhiro Okamoto]
23字：777（正文）;数字数量：1个;补充文件：0的整数;参考24页：1个;表格：025关键词：急性白血病、骨髓浸润、癌症基因组分析测试、原发性未知的癌症26、恶性小圆细胞肿瘤27恶性小圆细胞肿瘤（MSRCT）的特征是相对28的未分化细胞，常见于儿童实体瘤中，包括29的横纹肌肉瘤、神经母细胞瘤、尤文氏肉瘤和30的小细胞神经内分泌癌（SCNEC）（1）。MSRCT的鉴别诊断特别困难，因为它们的未分化或粗糙的特征。我们报告一例不明原因的32例原发性MSRCT，其伪装成白血病。一名16岁的女性一周前被转诊到综合医院，因为有4个月的间歇性左腰背部和腿部疼痛病史。既往和家族史35例无异常。4天前，患者因血小板减少症和高乳酸脱氢酶37（LD）水平在血液科36进行骨髓（BM）检查，诊断为急性淋巴细胞白血病（ALL），38岁时立即开始使用泼尼松龙。然而，治疗反应较差。39骨髓流式细胞术（FCM）检查结果为ALL阴性，由于怀疑儿童实体瘤41侵犯骨髓，40她被转移到我科。42患者警觉，但有严重的腰背痛，不能移动。43例体温为36.3 ℃。除面部苍白外，还观察到肝肿大，44但未观察到淋巴结病。初始实验室检查显示贫血和45例血小板减少症（白色血细胞计数：14，370/μL，无原始细胞;血红蛋白：46 9.3 g/dL;血小板计数：58× 103/μL）。LD和肌酸酐水平分别为4，918 IU/L和1.61
23 Word count: 777 (main text); Number of figures: 1; Supplemental files: 0; Reference24 pages: 1; Tables: 0 25 Key words: acute leukemia, bone marrow invasion, cancer genome profiling test, cancer 26 of unknown primary, malignant small round cell tumor 27 Malignant small round cell tumors (MSRCTs) are characterized by relatively 28 undifferentiated cells common in solid tumors among children, including 29 rhabdomyosarcomas, neuroblastomas, Ewing's sarcomas, and small cell neuroendocrine 30 carcinomas (SCNECs)(1). Differential diagnosis of MSRCTs is particularly difficult 31 because of their undifferentiated or crude characteristics. We report a case of an unknown 32 primary MSRCT, which masqueraded as leukemia. 33 A 16-year-old female was referred to the general hospital a week ago because of 34 a 4-month history of intermittent left lumbar back and leg pains. Past and family history 35 were unremarkable. She underwent bone marrow (BM) examination in the Hematology 36 Department 4 days ago because of thrombocytopenia and high lactate dehydrogenase 37(LD) levels, and was diagnosed with acute lymphocytic leukemia (ALL), and was 38 immediately initiated with prednisolone. However, the therapeutic response was poor. 39 The BM flow cytometry (FCM) examination was negative for ALL, and she was then 40 transferred to our department because of suspected BM invasion of a childhood solid 41 tumor.42 The patient was alert but had severe lumbar back pain and could not move. The 43 body temperature was 36.3 C. In addition to facial pallor, hepatomegaly was observed, 44 although no lymphadenopathy was noted. Initial laboratory workup revealed anemia and 45 thrombocytopenia (white blood cell count, 14,370/µL with no blast cells; hemoglobin, 46 9.3 g/dL; platelet count, 58× 103/μL). LD and creatinine levels were 4,918 IU/L and 1.61
影响因子：
2.1
作者：
De Miguel Sanchez, Carlos;Robles de Castro, Diego;Cordoba Alonso, Ana Isabel;Maria Guinea de Castro, Jose
通讯作者：
Maria Guinea de Castro, Jose
影响因子：
1.2
作者：
Kawashima, Ichiro;Fukasawa, Hiroko;Kirito, Keita
通讯作者：
Kirito, Keita