Spontaneous regression of a monoclonal proliferation of large granular lymphocytes associated with reversal of anemia and neutropenia.
Spontaneous regression of a monoclonal proliferation of large granular lymphocytes associated with reversal of anemia and neutropenia.
复制标题
与贫血和中性粒细胞减少症逆转相关的大颗粒淋巴细胞单克隆增殖的自发消退。
作者：
E. Winton;W. Chan;I. Check;K. Colenda;K. Bongiovanni;T. Waldmann
一位43岁男性，具有表型均一的扩增T细胞亚群，于1981年出现贫血和中性粒细胞减少症。99%的外周血淋巴细胞表面抗原表型为T3+、T8+、T4-，形态学上为大颗粒淋巴细胞（LGL）。这些细胞占骨髓有核细胞的37%。患者就诊后8个月，外周血T8+、LGL自发降低，贫血和中性粒细胞减少症完全消退。截至1984年10月，患者血液学保持正常。为了确定T8+，LGL是否代表克隆扩增，当患者贫血和贫血时，以及当他血液学正常时，从外周血淋巴细胞收集并冷冻保存的DNA进行克隆T细胞抗原受体基因重排分析。使用Southern印迹分析，克隆DNA重排被证明，这个克隆减少，但在1984年收集的外周血淋巴细胞中仍然是明显的。上述观察结果提示T_（8+）、LGL扩增参与了中性粒细胞减少症和贫血的发病机制，但其确切机制仍有待阐明。
A 43-year-old male with a phenotypically homogeneous, expanded subset of T cells presented in 1981 with anemia and neutropenia. The surface antigen phenotype of 99% of the peripheral blood lymphocytes was T3+, T8+, T4-, and they were morphologically large granular lymphocytes (LGL). The same cells comprised 37% of the marrow nucleated cells. Eight months after he presented, the peripheral blood T8+, LGL diminished spontaneously, and the anemia and neutropenia completely resolved. The patient remains hematologically normal as of October 1984. To determine if the T8+, LGL represented a clonal expansion, DNA from peripheral blood lymphocytes collected and cryopreserved when the patient was neutropenic and anemic, and when he was hematologically normal, was analyzed for clonal T-cell antigen receptor gene rearrangements. Using Southern blot analysis, a clonal DNA rearrangement was demonstrated, and this clone diminished but was still demonstrable in peripheral blood lymphocytes collected in 1984. The above observations implicate the expanded T8+, LGL in the pathogenesis of the neutropenia and anemia, yet the exact mechanism remains to be elucidated.
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慢性淋巴细胞增多症伴中性粒细胞减少症：与抗体介导的中性粒细胞破坏相关的新型异常 T 细胞群的证据。
DOI：
10.1016/0090-1229(83)90060-0
发表时间：
1983
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Starkebaum,G;Martin,PJ;Singer,JW;Lum,LG;Price,TH;Kadin,ME;Raskind,WH;Fialkow,PJ
通讯作者：
Fialkow,PJ
蕈样肉芽肿和皮肤病性淋巴结病中 T 细胞受体基因的克隆重排。
DOI：
10.1056/nejm198508293130903
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Weiss,LM;Hu,E;Wood,GS;Moulds,C;Cleary,ML;Warnke,R;Sklar,J
通讯作者：
Sklar,J
影响因子：
4.4
作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
通讯作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
慢性 T 细胞淋巴细胞增多症伴中性粒细胞减少症：单克隆抗体研究病例报告。
影响因子：
20.3
作者：
Aisenberg,AC;Wilkes,BM;Harris,NL;Ault,KA;Carey,RW
通讯作者：
Carey,RW
影响因子：
39.2
作者：
LOUGHRAN, TP;KADIN, ME;SLICHTER, SJ
通讯作者：
SLICHTER, SJ