Quantitative normative gait data in a large cohort of ambulatory persons with Parkinson's disease.
Quantitative normative gait data in a large cohort of ambulatory persons with Parkinson's disease.
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DOI：
10.1371/journal.pone.0042337
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
McFarland N
中科院分区：
文献类型：
--
作者：
Hass CJ;Malczak P;Nocera J;Stegemöller EL;Wagle Shukla A;Malaty I;Jacobson CE 4th;Okun MS;McFarland N
步态表现被广泛评估，以评估老年人的健康状况。虽然一些研究人员提出了规范值的时空步态参数从老年人人群，文献一直没有大规模的队列研究，这是为了提供定量的，规范的步态数据的人与帕金森氏病。本研究的目的是提供临床上重要的步态特征的参考值在一个大样本的非卧床帕金森氏病患者，以帮助临床医生和研究人员在他们的评估和治疗步态障碍。在310名患有特发性帕金森病的个体中收集步态表现，因为他们走过压力敏感的走道。14个定量步态参数进行了测量和评价Hoehn-Yahr病分期和性别。在所有分析中，控制了疾病持续时间和年龄。患有最严重帕金森氏症残疾的人比轻度和中度受影响的人群行走速度明显较慢，步数和步幅较短。此外，受影响最严重的患者花更多的时间双脚在地面上，并与中度残疾患者相比，步行时有更广泛的支持基础。在评估的任何步态参数上，轻度和中度残疾组之间没有检测到差异。在一个大的队列的动态帕金森氏病患者的14个步态参数的参考值，这些可能是非常有用的评估和解释个人的步态功能障碍。重要的是，临床医生和研究人员要认识到缺乏变化的定量参数，因为PD患者从轻度到中度步态障碍。
Gait performance is widely evaluated to assess health status in older adult populations. While several investigators have presented normative values for spatiotemporal gait parameters drawn from older adult populations, the literature has been void of large-scale cohort studies, which are needed in order to provide quantitative, normative gait data in persons with Parkinson’s disease. The aim of this investigation was to provide reference values for clinically important gait characteristics in a large sample of ambulatory persons with Parkinson’s disease to aid both clinicians and researchers in their evaluations and treatments of gait impairment. Gait performance was collected in 310 individuals with idiopathic Parkinson’s disease as they walked across a pressure sensitive walkway. Fourteen quantitative gait parameters were measured and evaluated with respect to Hoehn and Yahr disease staging and gender. Disease duration and age were controlled for in all analyses. Individuals with the greatest Parkinson’s disability walked significantly slower with shorter steps and stride lengths than the mild and moderately affected groups. Further, the most affected patients spent more time with both feet on the ground, and walked with a wider base of support than the moderately disabled patients. No differences were detected between the mild and moderate disability groups on any of the gait parameters evaluated. Reference values for 14 gait parameters in a large cohort of ambulatory patients with Parkinson’s disease are provided and these may be highly useful for assessing and interpreting an individual’s gait dysfunction. It is important for clinicians and researchers to appreciate the lack of change in quantitative parameters as PD patients move from mild to moderate gait impairment.
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DOI：
10.1111/j.1532-5415.1996.tb01404.x
发表时间：
1996-11-01
影响因子：
6.3
作者：
Judge, JO;Schechtman, K;Cress, E
通讯作者：
Cress, E
影响因子：
6.3
作者：
Oh-Park M;Holtzer R;Xue X;Verghese J
通讯作者：
Verghese J
影响因子：
6.7
作者：
Callisaya, Michele L.;Blizzard, Leigh;Srikanth, Velandai K.
通讯作者：
Srikanth, Velandai K.
DOI：
10.1093/geronj/24.2.169
发表时间：
1969-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
MURRAY, MP;KORY, RC;CLARKSON, BH
通讯作者：
CLARKSON, BH
影响因子：
5
作者：
Ostir, Glenn V.;Kuo, Yong-Fang;Ottenbacher, Kenneth J.
通讯作者：
Ottenbacher, Kenneth J.