Strategies for Supersaturated Screening: Group Orthogonal and Constrained Var(s) Designs
Strategies for Supersaturated Screening: Group Orthogonal and Constrained Var(s) Designs
复制标题
过饱和筛选策略：分组正交和约束 Var(s) 设计
作者：
Maria L. Weese;Jonathan W. Stallrich;Byran J. Smucker;David J. Edwards
摘要尽管有大量关于过饱和设计（SSD）的文献，但实际使用的记录却很少。我们认为这种不平衡是由于文献中关于SSD使用的相互矛盾的建议以及设计无法满足从业者的分析期望。为了解决这些问题，我们首先总结从业者的关注和期望的SSD通过非正式的问卷调查确定。接下来，我们将讨论和比较两种最新的SSD，它们将设计构造方法与特定的分析方法配对。设计/分析配对的选择取决于筛选目标。当与我们新的修改后的分析配对时，组正交SSD被证明具有高功率，即使有许多活跃因素。当效应方向可以事先合理指定时，建议使用约束正方差最优设计与Dantzig选择器搭配使用;该策略合理地控制了I类错误率，同时仍能识别出高比例的活跃因子。
Abstract Despite the vast amount of literature on supersaturated designs (SSDs), there is a scant record of their use in practice. We contend this imbalance is due to conflicting recommendations regarding SSD use in the literature as well as the designs’ inabilities to meet practitioners’ analysis expectations. To address these issues, we first summarize practitioner concerns and expectations of SSDs as determined via an informal questionnaire. Next, we discuss and compare two recent SSDs that pair a design construction method with a particular analysis method. The choice of a design/analysis pairing is shown to depend on the screening objective. Group orthogonal SSDs, when paired with our new, modified analysis, are demonstrated to have high power even with many active factors. Constrained positive Var(s)-optimal designs, when paired with the Dantzig selector, are recommended when effect directions can be credibly specified in advance; this strategy reasonably controls Type I error rates while still identifying a high proportion of active factors.
存在相互作用时的筛选策略
影响因子：
2.5
作者：
Draguljic D
通讯作者：
Draguljic D