Evidence for a shared genetic susceptibility to migraine and epilepsy.
Evidence for a shared genetic susceptibility to migraine and epilepsy.
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DOI：
10.1111/epi.12072
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发表时间：
2013-02
期刊：
影响因子：
5.6
通讯作者：
EPGP Investigators
中科院分区：
文献类型：
--
作者：
Winawer MR;Connors R;EPGP Investigators
虽然已知癫痫和偏头痛在个体中同时发生，但共同的遗传易感性对这种合并症的贡献尚不清楚。我们在癫痫表型/基因组计划（EPGP）队列中研究了偏头痛和癫痫共享遗传效应的假设。我们研究了730名年龄≥12岁的EPGP参与者中患有非获得性局灶性癫痫（NAFE）或全身性癫痫（GE）的患病率，这些患者来自501个家庭，家庭中有≥2名原因不明的癫痫患者。无先兆偏头痛（MO）和有先兆偏头痛（MA）的信息使用≥12岁个体验证的仪器收集。由于许多人同时患有MO和MA，我们考虑了两组不重叠的偏头痛患者：那些在任何头痛中符合MA标准的人（MA）和那些不符合MA标准的人（“只有MA”）。对EPGP参与者进行访谈，了解其他非参与家庭成员的癫痫发作病史。我们评估了入选受试者偏头痛患病率与其他非入选亲属癫痫发作家族史的关系，使用广义估计方程来控制家庭内观察结果的非独立性。在有≥2个额外一级亲属的参与者中，MA病史（但不只是MA）的患病率显著增加。这些发现支持了癫痫和MA具有共同遗传易感性的假设。
Although epilepsy and migraine are known to co-occur within individuals, the contribution of a shared genetic susceptibility to this comorbidity remains unclear. We investigated the hypothesis of shared genetic effects on migraine and epilepsy in the Epilepsy Phenome/Genome Project (EPGP) cohort. We studied prevalence of a history of migraine in 730 EPGP participants aged ≥12 years with non-acquired focal epilepsy (NAFE) or generalized epilepsy (GE) from 501 families containing ≥2 individuals with epilepsy of unknown cause. Information on migraine without aura (MO) and migraine with aura (MA) was collected using an instrument validated for individuals ≥12 years. Since many individuals have both MO and MA, we considered two non-overlapping groups of individuals with migraine: those who met criteria for MA in any of their headaches (MA), and those who did not (“MO-only”). EPGP participants were interviewed about the history of seizure disorders in additional non-enrolled family members. We evaluated associations of migraine prevalence in enrolled subjects with family history of seizure disorders in additional non-enrolled relatives, using generalized estimating equations to control for the non-independence of observations within families. Prevalence of a history of MA (but not MO-only) was significantly increased in enrolled participants with ≥2 additional affected first degree relatives. These findings support the hypothesis of a shared genetic susceptibility to epilepsy and MA.
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DOI：
10.1016/j.ijmedinf.2012.03.004
发表时间：
2013-04-01
影响因子：
4.9
作者：
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通讯作者：
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影响因子：
9.9
作者：
OTTMAN, R;LIPTON, RB
通讯作者：
LIPTON, RB