A cross-sectional study of Q fever in Camels: risk factors for infection, the role of small ruminants and public health implications for desert-dwelling pastoral communities
A cross-sectional study of Q fever in Camels: risk factors for infection, the role of small ruminants and public health implications for desert-dwelling pastoral communities
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骆驼 Q 热的横断面研究：感染的危险因素、小型反刍动物的作用以及对沙漠牧区的公共卫生影响
DOI：
10.1101/2022.04.27.22274356
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Holloway P
中科院分区：
文献类型：
--
作者：
Holloway P
Q热是一种重要的“被忽视的人畜共患病”，在中东地区有很高的发病率。在该地区的农村沙漠居住社区中，骆驼奶主要是生食的，因为人们认为单峰骆驼是古兰经和伊斯兰圣训中提到的一种独特的清洁牲畜，而其他牲畜的奶通常是煮沸的。因此，骆驼在这些社区中构成了一种独特的公共卫生威胁，其中包括贝氏柯克斯体（Coxiella burnetii）。鉴于此，2017年9月至2018年10月期间，在约旦南部的单峰骆驼群中进行了一项横断面研究，包括随机选择的121个牛群中的404头骆驼。此外，对与这些牛群相关的510名家庭成员进行了关于人畜共患病传播的潜在高风险做法的访谈。体重校正的骆驼群体伯氏梭菌血清阳性率为49.6%（95%CI：44.7-54.5），有证据表明≤6月龄的小牛存在母源性免疫。校正的畜群水平患病率为76.0%（95% CI 72.7-80.2）。据估计，30.4%（144/477）的个体每月或每月以上食用感染牛群的生奶。在多变量逻辑回归分析后，发现骆驼血清阳性状态与年龄增加、牛群蜱虫负担高、全年保持牛群在一起（包括产犊时）以及拥有较大（>50）绵羊和山羊群有关，其中山羊的风险高于绵羊。赛骆驼的地位被认为是保护性的。应考虑采取适当的社会文化干预措施，提高人们对饮用生骆驼奶的潜在风险的认识，同时采取适当的牲畜管理干预措施。
Q fever represents an important ‘neglected zoonosis’, with high prevalences recorded across the Middle East region. Among rural desert‐dwelling communities in the region, camel milk is largely consumed raw, due to perceptions of dromedaries as a uniquely clean livestock species mentioned in the Qur'an and Islamic hadith, while milk from other livestock species is usually boiled. As a result, camels present a unique public health threat among such communities from milk‐borne pathogens, includingCoxiella burnetii.In view of this, a cross‐sectional study was conducted among dromedary herds in southern Jordan between September 2017 and October 2018, including 404 camels from 121 randomly selected herds. In addition, 510 household members associated with these herds were interviewed regarding potential high‐risk practices for zoonotic transmission. Weight adjusted camel population seroprevalence forC. burnetiiwas 49.6% (95% CI: 44.7–54.5), with evidence of maternally derived immunity in calves ≤6 months old. Adjusted herd‐level prevalence was 76.0% (95% CI 72.7–80.2). It was estimated 30.4% (144/477) of individuals consumed raw milk from infected herds monthly or more. Following multivariable logistic regression analysis, seropositive status in camels was found to be associated with increasing age, high herd tick burdens, keeping the herd together throughout the year including when calving, and owning larger (>50) sheep and goat flocks, with goats presenting a higher risk than sheep. Racing camel status was found to be protective. Socioculturally appropriate interventions aimed at raising awareness of potential risks associated with drinking raw camel milk, alongside appropriate livestock management interventions, should be considered.
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影响因子：
2.6
作者：
Canevari JT;Firestone SM;Vincent G;Campbell A;Tan T;Muleme M;Cameron AWN;Stevenson MA
通讯作者：
Stevenson MA
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DOI：
--
发表时间：
2019
期刊：
Comparative Immunology, Microbiology & Infectious Diseases
影响因子：
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作者：
Abdelfattah M Selim;A. Ali
通讯作者：
A. Ali
影响因子：
11.8
作者：
Hogerwerf L;van den Brom R;Roest HI;Bouma A;Vellema P;Pieterse M;Dercksen D;Nielen M
通讯作者：
Nielen M
慢性Q热：法国92例，其中27例无心内膜炎
DOI：
--
发表时间：
1993
期刊：
影响因子：
--
作者：
P. Brouqui;H. Dupont;M. Drancourt;Y. Berland;J. Etienne;C. Leport;F. Goldstein;Philippe Massip;M. Micoud;André Bertrand;D. Raoult
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D. Raoult
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影响因子：
2.6
作者：
O. El
通讯作者：
O. El