Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, The Netherlands.
Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, The Netherlands.
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DOI：
10.3201/eid1703.101157
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发表时间：
2011-03
影响因子：
11.8
通讯作者：
Nielen M
中科院分区：
文献类型：
--
作者：
Hogerwerf L;van den Brom R;Roest HI;Bouma A;Vellema P;Pieterse M;Dercksen D;Nielen M
最近，荷兰的人类Q热病例数量急剧增加。为了应对这种增加，奶山羊和奶绵羊接种了贝氏柯克斯体疫苗。所有怀孕的奶山羊和奶绵羊群中的Q热阳性被淘汰。我们确定了疫苗接种对小反刍动物细菌脱落的影响。在剔除当天，从13个畜群的957只妊娠动物中采集子宫液、阴道粘液和乳汁样本。与未接种疫苗的动物相比，接种疫苗的动物中的患病率和细菌负荷降低。这些影响在动物第一次怀孕期间最为明显。结果表明，接种疫苗可以减少环境中的细菌负荷和人类暴露于C。伯内特氏菌
Recently, the number of human Q fever cases in the Netherlands increased dramatically. In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii. All pregnant dairy goats and dairy sheep in herds positive for Q fever were culled. We identified the effect of vaccination on bacterial shedding by small ruminants. On the day of culling, samples of uterine fluid, vaginal mucus, and milk were obtained from 957 pregnant animals in 13 herds. Prevalence and bacterial load were reduced in vaccinated animals compared with unvaccinated animals. These effects were most pronounced in animals during their first pregnancy. Results indicate that vaccination may reduce bacterial load in the environment and human exposure to C. burnetii.
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影响因子：
11.8
作者：
TSELENTIS, Y;GIKAS, A;TSAPARAS, N
通讯作者：
TSAPARAS, N
影响因子：
1.8
作者：
Van den Brom, R.;Vellema, P.
通讯作者：
Vellema, P.
影响因子：
13.6
作者：
Lyytikainen, O;Ziese, T;Petersen, L
通讯作者：
Petersen, L
DOI：
10.1098/rspb.2010.0575
发表时间：
2010-09-22
影响因子：
4.7
作者：
Courcoul, Aurelie;Vergu, Elisabeta;Beaudeau, Francois
通讯作者：
Beaudeau, Francois
影响因子：
5.5
作者：
Gidding, Heather F.;Wallace, Cate;McIntyre, Peter B.
通讯作者：
McIntyre, Peter B.