Behavioral Inhibition of Circadian Responses to Light
Behavioral Inhibition of Circadian Responses to Light
复制标题
昼夜节律对光反应的行为抑制
DOI：
--
复制
发表时间：
1992
影响因子：
3.5
通讯作者：
Nicholas Mrosovsky
中科院分区：
文献类型：
--
作者：
M. Ralph;Nicholas Mrosovsky
啮齿动物的昼夜运动节律可以通过产生节律相移的光或非光事件来同步。然而，人们对这两种类型的刺激如何相互作用产生夹带作用知之甚少。在短光脉冲和运动活动（非光事件）同时发生的情况下，检查了金仓鼠的昼夜节律光反应。当动物在光照期间活跃时，光诱导的相位提前会减弱。结果表明，昼夜节律对光的反应取决于给予光的环境状况，并对昼夜节律研究中的隐含假设提出了质疑，即相移和光暗循环的夹带仅取决于众所周知的视网膜离走通路的光激活。此外，由于光疗法正在成为治疗人类昼夜节律紊乱的重要组成部分，因此结果强调需要评估光疗法方案的行为方面。
Circadian locomotor rhythms in rodents may be synchronized by either photic or nonphotic events that produce phase shifts of the rhythm. Little is known, however, about how these two types of stimuli interact to produce entrainment. The well-characterized circadian photic response of the golden hamster was examined in situations where a short light pulse and locomotor activity, a nonphotic event, occurred simultaneously. Light-induced phase advances were attenuated when animals were active during light exposure. The results show that circadian responses to light depend upon the environmental situation in which the light is given, and call into question the implicit assumption in circadian rhythm research that phase shifting and entrainment to light-dark cycles depend simply on photic activation of well-known retinofugal pathways. Moreover, since light therapy is becoming an important component in the treatment of circadian-based disorders in humans, the results emphasize the need for evaluation of the behavioral aspects of light therapy protocols.
季节性情感障碍：非芬戈动物模型。
影响因子：
3.5
作者：
Zucker,I
通讯作者：
Zucker,I
影响因子：
--
作者：
EDGAR, DM;DEMENT, WC
通讯作者：
DEMENT, WC