Abnormal striatal BOLD responses to reward anticipation and reward delivery in ADHD.
Abnormal striatal BOLD responses to reward anticipation and reward delivery in ADHD.
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DOI：
10.1371/journal.pone.0089129
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Moll J
中科院分区：
文献类型：
--
作者：
Furukawa E;Bado P;Tripp G;Mattos P;Wickens JR;Bramati IE;Alsop B;Ferreira FM;Lima D;Tovar-Moll F;Sergeant JA;Moll J
改变的奖赏处理被认为是引起注意缺陷多动障碍（ADHD）症状的原因。这种改变背后的神经生物学机制尚不清楚。我们假设，多巴胺释放从奖励到奖励预测线索的转移，正如通常在动物研究中观察到的那样，可能是ADHD的缺陷。采用功能磁共振成像（fMRI）技术，在经典条件反射范式下研究了纹状体对奖励预测线索和奖励传递的反应。来自14名高功能和兴奋剂初治的年轻成年人（8名男性，6名女性）和15名匹配良好的对照组（8名男性，7名女性）的数据被纳入分析。在奖励预期，增加血氧水平依赖（BOLD）的反应，在右腹侧和左背侧纹状体中观察到的控制，但不是在ADHD组。相反的模式，观察到在响应奖励交付，ADHD组表现出显着更大的BOLD反应，在腹侧纹状体双边和左背侧纹状体相对于对照组。在ADHD组中，当前多动/冲动症状的数量与奖励预期期间的腹侧纹状体反应呈负相关，与奖励反应呈正相关。在纹状体中观察到的BOLD反应模式与ADHD中预测性多巴胺信号传导受损一致，这可能解释了ADHD的奖励相关行为和症状的改变。
Altered reward processing has been proposed to contribute to the symptoms of attention deficit hyperactivity disorder (ADHD). The neurobiological mechanism underlying this alteration remains unclear. We hypothesize that the transfer of dopamine release from reward to reward-predicting cues, as normally observed in animal studies, may be deficient in ADHD. Functional magnetic resonance imaging (fMRI) was used to investigate striatal responses to reward-predicting cues and reward delivery in a classical conditioning paradigm. Data from 14 high-functioning and stimulant-naïve young adults with elevated lifetime symptoms of ADHD (8 males, 6 females) and 15 well-matched controls (8 males, 7 females) were included in the analyses. During reward anticipation, increased blood-oxygen-level-dependent (BOLD) responses in the right ventral and left dorsal striatum were observed in controls, but not in the ADHD group. The opposite pattern was observed in response to reward delivery; the ADHD group demonstrated significantly greater BOLD responses in the ventral striatum bilaterally and the left dorsal striatum relative to controls. In the ADHD group, the number of current hyperactivity/impulsivity symptoms was inversely related to ventral striatal responses during reward anticipation and positively associated with responses to reward. The BOLD response patterns observed in the striatum are consistent with impaired predictive dopamine signaling in ADHD, which may explain altered reward-contingent behaviors and symptoms of ADHD.
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