Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability.
Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability.
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DOI：
10.1111/gbb.12170
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Holly Fitch R
中科院分区：
文献类型：
--
作者：
Truong DT;Che A;Rendall AR;Szalkowski CE;LoTurco JJ;Galaburda AM;Holly Fitch R
Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing, visual attention, and working memory. Genetic variants in DCDC2 have been associated with dyslexia, impairments in phonological processing, and in short term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre-pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working versus reference memory), and rotarod (to examine sensorimotor ability and motor learning) were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in rapid auditory processing, working memory, and reference memory in Dcdc2del2/del2 mice as compared to matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
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影响因子：
6.1
作者：
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通讯作者：
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影响因子：
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Kilgard, M. P.
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16.2
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