Correlation between Platelet Gelsolin and Platelet Activation Level in Acute Myocardial Infarction Rats and Intervention Effect of Effective Components of Chuanxiong Rhizome and Red Peony Root.
Correlation between Platelet Gelsolin and Platelet Activation Level in Acute Myocardial Infarction Rats and Intervention Effect of Effective Components of Chuanxiong Rhizome and Red Peony Root.
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急性心肌梗死大鼠血小板凝溶胶蛋白与血小板活化水平的相关性及川芎、赤芍有效成分的干预作用
DOI：
10.1155/2013/985746
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Liu Y;Yin H;Jiang Y;Xue M;Guo C;Shi D;Chen K
血小板凝溶胶蛋白在急性心肌梗死血小板活化中的生物学作用尚不明确。为了给中药抗血小板治疗提供新的靶点，并进一步阐明中药有效成分赤芍和川芎的作用，本研究将Sprague道利大鼠随机分为冠状动脉左前降支结扎组和假手术组，并以不同药物预防作为对照。结果发现，模型大鼠血浆凝溶胶蛋白在富血小板血浆中高表达，在贫血小板血浆中低表达，并伴有高血小板活化水平;模型大鼠血浆肌动蛋白微丝和血小板钙离子平均荧光强度（MFI）增加，血浆维生素D结合蛋白降低。雄芍胶囊可同时抑制富血小板血浆和缺血心肌凝溶胶蛋白的表达，降低血浆F-actin水平和血小板钙离子MFI。我们的研究得出结论，血小板凝溶胶蛋白是血小板活化的重要贡献者，血小板凝溶胶蛋白抑制剂可能成为抗血小板治疗的新靶点。结论：芎芍胶囊具有抗血小板和阿司匹林样心脏保护作用，是一种很有前途的中药制剂。
The biological role of platelet gelsolin in platelet activation of acute myocardial infarction is not defined. In order to provide a potential new antiplatelet target for Chinese medicine and to elucidate the contribution of Xiongshao capsule, the effective components of Chuanxiong rhizome and red peony root, in this study, we randomly allocated Sprague Dawley rats to left anterior descending coronary artery ligation or sham surgery and different drug prophylaxis as control. We found that gelsolin is highly expressed in platelet rich plasma and lowly expressed in platelet poor plasma, accompanied by the high platelet activation level in model rats; plasma actin filaments and mean fluorescence intensity (MFI) of platelet calcium ion increased and plasma vitamin D binding protein decreased in model rats. Xiongshao capsule could inhibit the gelsolin expression in platelet rich plasma and ischemic heart tissue simultaneously and reduce the level of plasma F-actin and MFI of platelet calcium ion. Our study concludes that platelet gelsolin is an important contributor to platelet activation, and platelet gelsolin inhibition may form a novel target for antiplatelet therapy. Xiongshao capsule may be a promising Chinese medicine drug for antiplatelet and aspirin-like cardioprotection effect.
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影响因子：
37.8
作者：
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通讯作者：
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作者：
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影响因子：
2.9
作者：
Liu Yue;Yin Hui-jun;Chen Ke-ji
通讯作者：
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