The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn.
The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn.
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DOI：
10.1016/j.burns.2016.02.005
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发表时间：
2016-09
期刊：
影响因子：
2.7
通讯作者：
Bucala, Richard
中科院分区：
文献类型：
--
作者：
Kim, Bong-Sung;Stoppe, Christian;Grieb, Gerrit;Leng, Lin;Sauler, Maor;Assis, David;Simons, David;Boecker, Arne Hendrick;Schulte, Wibke;Piecychna, Marta;Hager, Stephan;Bernhagen, Juergen;Pallua, Norbert;Bucala, Richard
我们早些时候报道，细胞因子巨噬细胞移动抑制因子(MIF)是一种潜在的烧伤生物标志物。本研究探讨了新发现的MIF家族成员D-DOPAChrome互变酶(DDT或MIF-2)及其共同的可溶性受体CD74(SCD74)在严重烧伤患者中的表达水平及其临床意义。测定20例严重烧伤患者和20例健康体检者的血清DDT和sCD74水平。血清水平与烧伤严重指数(ABSI)和烧伤面积(TBSA)相关，然后进行受试者工作特征(ROC)分析。31名烧伤患者和28名健康对照的基因表达数据集分析支持数据。烧伤患者CD74、DDT升高。此外，与存活者相比，败血症死亡患者的CD74和DDT也升高。伤后早期血清DDT水平与ABSI、TBSA呈正相关，其中以伤后24小时的预测能力最强。血清CD74水平仅与伤后5天的ABSI相关。DDT可能有助于监测烧伤后早期的临床转归和预测脓毒症。相比之下，sCD74和MIF作为早期死亡预测指标的价值有限，因为它们对烧伤的反应迟缓。
We reported earlier that the cytokine macrophage migration inhibitory factor (MIF) is a potential biomarker in burn injury. In the present study, we investigated the clinical significance in severely burned patients of expression levels the newly discovered MIF family member D-dopachrome tautomerase (DDT or MIF-2) and their common soluble receptor CD74 (sCD74). DDT and sCD74 serum levels were measured 20 severely burned patients and 20 controls. Serum levels were correlated to the abbreviated burn severity index (ABSI) and TBSA followed by receiver operating characteristic (ROC) analysis. Data were supported by gene expression dataset analysis of 31 burn patients and 28 healthy controls. CD74 and DDT were increased in burn patients. Furthermore, CD74 and DDT also were elevated in septic non-survivors when compared to survivors. Serum levels of DDT showed a positive correlation with the ABSI and TBSA in the early stage after burn injury, and the predictive character of DDT was strongest at 24 hrs. Serum levels of CD74 only correlated with the ABSI five days post-injury. DDT may assist in the monitoring of clinical outcome and prediction of sepsis during the early post-burn period. sCD74 and MIF, by contrast, have limited value as an early predictor of death due to their delayed response to burn injury.
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