Visual illusion susceptibility in autism: A neural model.
Visual illusion susceptibility in autism: A neural model.
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DOI：
10.1111/ejn.15739
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发表时间：
2022-08
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影响因子：
--
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中科院分区：
文献类型：
--
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虽然在自闭症谱系障碍（ASD）患者中报告了非典型感觉知觉，但导致感觉知觉中断的自闭症潜在神经机制仍不清楚。我们开发了一个神经模型与关键的生理，功能和神经解剖学参数，以调查机制的代表性范围内的视错觉相关的方向感知在典型的发达国家的主题相比，个人与ASD。我们的研究结果表明，两种理论上的自闭症特征，兴奋/抑制失衡和自上而下调制的减弱，可能是降低某些视觉错觉敏感性的潜在候选者。皮质抑制，兴奋/抑制的平衡，一方面从更高的视觉区域的反馈和易感性的一类视错觉有关的方向知觉，另一方面之间的参数相关性提供了机会，调查不同的感觉处理机制在ASD的贡献和复杂的相互作用。本研究中使用的新方法可用于联系行为，功能和神经病理学研究;估计和预测ASD的感知和认知异质性;并为开发新的诊断和治疗方法奠定基础。自闭症患者对外部世界的感知，包括视觉场景，都不同。为了更好地了解自闭症患者大脑的潜在变化，我们开发了一种神经模型，可以模仿我们大脑的视觉系统，并表明自闭症患者不太容易受到一些视觉错觉的影响，因为大脑布线的潜在变化。这项工作可以形成自闭症异质性研究和新诊断方法开发的框架。
While atypical sensory perception is reported among individuals with autism spectrum disorder (ASD), the underlying neural mechanisms of autism that give rise to disruptions in sensory perception remain unclear. We developed a neural model with key physiological, functional and neuroanatomical parameters to investigate mechanisms underlying the range of representations of visual illusions related to orientation perception in typically developed subjects compared to individuals with ASD. Our results showed that two theorized autistic traits, excitation/inhibition imbalance and weakening of top‐down modulation, could be potential candidates for reduced susceptibility to some visual illusions. Parametric correlation between cortical suppression, balance of excitation/inhibition, feedback from higher visual areas on one hand and susceptibility to a class of visual illusions related to orientation perception on the other hand provide the opportunity to investigate the contribution and complex interactions of distinct sensory processing mechanisms in ASD. The novel approach used in this study can be used to link behavioural, functional and neuropathological studies; estimate and predict perceptual and cognitive heterogeneity in ASD; and form a basis for the development of novel diagnostics and therapeutics. Individuals with autism perceive the external world, including visual scenes, differently. To better understand potential brain changes in autism, we developed a neural model that can mimic our brain's visual system and showed that people with autism are less susceptible to some visual illusions, because of potential changes in brain wiring. This work can form a framework for the study of autism heterogeneity and the development of new diagnostics.
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影响因子：
1.8
作者：
Clifford, Colin W. G.
通讯作者：
Clifford, Colin W. G.
影响因子：
64.8
作者：
BLAKEMOR.C;CARPENTE.RH;GEORGESO.MA
通讯作者：
GEORGESO.MA
DOI：
10.1111/j.1469-7610.2004.00237.x
发表时间：
2004-03-01
影响因子：
7.6
作者：
Brosnan, MJ;Scott, FJ;Pye, J
通讯作者：
Pye, J
影响因子：
3.7
作者：
Ariza, Jeanelle;Rogers, Haille;Martinez-Cerdeno, Veronica
通讯作者：
Martinez-Cerdeno, Veronica
影响因子：
--
作者：
Bullier, J
通讯作者：
Bullier, J