Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway.
Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway.
复制标题
棕榈酸通过TLR 4/TRIF-Peli 1-pNF-κB途径促进黑色素瘤肺转移
DOI：
10.3390/metabo12111132
复制
发表时间：
2022-11-17
期刊：
影响因子：
4.1
通讯作者：
Zhu Y
中科院分区：
文献类型：
--
作者：
Zhang X;Li X;Xiong G;Yun F;Feng Y;Ni Q;Wu N;Yang L;Yi Z;Zhang Q;Yang Z;Kuang Y;Sai B;Zhu Y
高脂肪饮食在加重癌症方面起着重要作用。棕榈酸（Palmitic acid，PA）是饱和脂肪酸的组成成分之一，有报道其可促进黑色素瘤的增殖，但其介导的信号转导途径尚不清楚。本研究表明棕榈酸可促进黑色素瘤的肺转移。此外，棕榈酸和Toll样受体4（TLR 4）之间的相互作用进行了分子对接预测。实验结果证明棕榈酸可促进TLR 4和Toll/IL-1受体结构域的衔接子诱导IFN-β（TRIF）的表达。TLR 4抑制后，Pellino 1（Peli 1）的表达和NF-κB的磷酸化（pNF-κB）水平下调，Peli 1的沉默也抑制NF-κB的磷酸化。因此，软脂酸通过TLR 4/TRIF-Peli 1-pNF-κB通路促进黑色素瘤的肺转移。
A high-fat diet plays an important role in aggravating cancers. Palmitic acid (PA) is one of the components of saturated fatty acids; it has been reported to promote tumor proliferation in melanomas, but the signal transduction pathway mediated by palmitic acid remains unclear. This study showed that palmitic acid can promote the lung metastasis of melanomas. Moreover, the interaction between palmitic acid and toll-like receptor 4 (TLR4) was predicted by molecular docking. The experimental results proved that palmitic acid could promote the TLR4 and Toll/IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF) expression. The expression of Pellino1 (Peli1) and the phosphorylation of NF-kappa B (pNF-κB) were downregulated after the suppression of TLR4 and the silencing of Peli1 also inhibited the phosphorylation of NF-κB. Therefore, we concluded that palmitic acid promoted the lung metastasis of melanomas through the TLR4/TRIF-Peli1-pNF-κB pathway.
登录
查看更多内容
影响因子：
19
作者：
Bakir B;Chiarella AM;Pitarresi JR;Rustgi AK
通讯作者：
Rustgi AK
PELI1促进了TRIF依赖性Toll样受体信号传导和促炎性细胞因子的产生。
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
2.6
作者：
An J;Guo Y;Wang T;Pantuck AJ;Rettig MB
通讯作者：
Rettig MB
影响因子：
2.9
作者：
Lu, Shuming;Zhang, Zhuqing;Li, Yan
通讯作者：
Li, Yan
影响因子：
4.8
作者：
Kwan, Hiu Yee;Fu, Xiuqiong;Yu, Zhi-Ling
通讯作者：
Yu, Zhi-Ling