Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice.
Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice.
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DOI：
10.1016/j.celrep.2021.109234
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发表时间：
2021-06-15
期刊：
影响因子：
8.8
通讯作者：
Muzzio IA
中科院分区：
文献类型：
--
作者：
Yuan RK;Lopez MR;Ramos-Alvarez MM;Normandin ME;Thomas AS;Uygun DS;Cerda VR;Grenier AE;Wood MT;Gagliardi CM;Guajardo H;Muzzio IA
睡眠质量差与年龄相关的认知能力下降有关，这些改变是否可能逆转尚不清楚。在这项研究中，我们报告了睡眠剥夺（SD）如何影响年轻和老年小鼠的海马表征，睡眠模式和记忆。训练后，在一个校园依赖的对象-位置识别（OPR）的任务，控制动物睡眠随意，虽然实验动物进行5小时的SD，然后恢复睡眠。年轻的对照组和老年SD小鼠表现出成功的OPR记忆，而年轻的SD和老年对照组小鼠受损。成功的表现与两种细胞表型相关：（1）“上下文”细胞，在整个训练和测试过程中保持稳定，以及（2）“对象配置”细胞，当对象被引入上下文和测试过程中时重新映射。此外，有效记忆与非快速眼动（NREM）/快速眼动（REM）sigma转换期间的纺锤体计数相关。这些结果表明SD可能有助于改善与年龄相关的记忆缺陷，并使海马代表能够适应不断变化的环境。与睡眠相关的认知能力下降与睡眠质量差有关。Yuan等人表明，急性睡眠剥夺对老年小鼠的睡眠微结构、记忆和海马表征具有有益的影响，而对年轻动物具有相反的影响。这些发现表明，急性睡眠剥夺可能有助于减轻与年龄相关的认知能力下降。
Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, and memory in young and old mice. After training in a hippocampus-dependent object-place recognition (OPR) task, control animals sleep ad libitum, although experimental animals undergo 5 h of SD, followed by recovery sleep. Young controls and old SD mice exhibit successful OPR memory, whereas young SD and old control mice are impaired. Successful performance is associated with two cellular phenotypes: (1) “context” cells, which remain stable throughout training and testing, and (2) “object configuration” cells, which remap when objects are introduced to the context and during testing. Additionally, effective memory correlates with spindle counts during non-rapid eye movement (NREM)/rapid eye movement (REM) sigma transitions. These results suggest SD may serve to ameliorate age-related memory deficits and allow hippocampal representations to adapt to changing environments. Age-related cognitive decline is associated with poor sleep quality. Yuan et al. show that acute sleep deprivation has beneficial effects on sleep microarchitecture, memory, and hippocampal representations in old mice and has opposite effects in young animals. These findings suggest that acute sleep deprivation may serve to mitigate age-related cognitive decline.
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影响因子：
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