Rapid and reversible astrocytic reaction to afferent activity blockade in chick cochlear nucleus
Rapid and reversible astrocytic reaction to afferent activity blockade in chick cochlear nucleus
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鸡耳蜗核传入活动阻断的快速可逆星形胶质细胞反应
DOI：
10.1523/jneurosci.12-03-01001.1992
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发表时间：
1992
影响因子：
7.3
通讯作者：
E. Rubel
中科院分区：
文献类型：
--
作者：
KS Canady;E. Rubel
在此，我们描述了在传入神经的动作电位被阻断后，雏鸡耳蜗核内胶质纤维酸性蛋白(GFAP)免疫反应阳性的星形细胞突起迅速增殖。迷路内注射河豚毒素，阻断单侧第8神经活动。在活动阻断后1小时内，同侧耳蜗核GFAP免疫反应突起的面密度较对侧增加56%。这一增长在3小时内达到了152%。TTX注射后1周，第8神经活动恢复，对侧耳蜗核GFAP免疫反应无明显差异。这是首次报道在没有神经病理学的情况下，对记录的神经元不活动所产生的神经胶质反应。这些结果表明，神经元活动可能调节星形细胞突起的结构。
We describe here rapid proliferation of astrocytic processes immunoreactive for glial fibrillary acidic protein (GFAP) in the chick cochlear nucleus following blockade of action potentials in the afferent nerve. Unilateral eighth nerve activity blockade was achieved through intralabyrinthine injection of TTX. Within 1 hr of activity blockade, a 56% increase in area density of GFAP-immunoreactive processes was found in the ipsilateral cochlear nucleus as compared to the contralateral side of the brain. This increase reached 152% by 3 hr. When eighth nerve activity was allowed to recover and animals were studied 1 week after TTX injection, no difference was found in GFAP immunoreactivity between the ipsilateral and contralateral cochlear nuclei. This is the first report of a glial reaction to documented neuronal inactivity in the absence of neuropathology. These results indicate that neuronal activity may regulate the structure of astrocytic processes.
DOI：
10.1002/neu.480210112
发表时间：
1990
期刊：
Journal of neurobiology
影响因子：
--
作者：
E. Rubel;R. L. Hyson;D. Durham
通讯作者：
E. Rubel;R. L. Hyson;D. Durham