The golden age: gold nanoparticles for biomedicine.
The golden age: gold nanoparticles for biomedicine.
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DOI：
10.1039/c1cs15237h
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发表时间：
2012-04-07
影响因子：
46.2
通讯作者：
El-Sayed MA
中科院分区：
文献类型：
--
作者：
Dreaden EC;Alkilany AM;Huang X;Murphy CJ;El-Sayed MA
自从三个多世纪前第一次胶体合成以来，金纳米粒子已被用于生物医学应用。然而，在过去的二十年里，由于其在艺术和古代医学中的历史应用以及目前在增强光电子学和光电子学中的应用，它们美丽的颜色和独特的电子特性也引起了人们的极大关注。尽管金纳米粒子的炼金术起源并不高，但它所表现出的物理性质确实不同于小分子和大块材料，也不同于其他纳米级粒子。它们独特的性能组合刚刚开始在医疗诊断和治疗应用中得到充分实现。这篇评论将深入了解这些人工分子在生物医学中的设计、合成、功能化和应用，并讨论它们与生物系统的相互作用，以改善患者的健康。此外，我们提供了一个调查的迅速扩大的机构的文献就这一主题，并认为，黄金纳米技术使生物医学不仅仅是一个行为的“镀金（纳米医学）百合”，但一个新的“黄金时代”的生物医学纳米技术是真正的我们。展望未来，我们面前最具挑战性的纳米科学将是找到新的化学和物理方法，用化合物使金纳米粒子功能化，这些化合物可以促进有效的结合，清除和生物相容性，并评估它们对其他生物系统的安全性及其对人类健康和生殖的长期影响。
Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago. However, over the past two decades, their beautiful colors and unique electronic properties have also attracted tremendous attention due to their historical applications in art and ancient medicine and current applications in enhanced optoelectronics and photovoltaics. In spite of their modest alchemical beginnings, gold nanoparticles exhibit physical properties that are truly different from both small molecules and bulk materials, as well as from other nanoscale particles. Their unique combination of properties is just beginning to be fully realized in range of medical diagnostic and therapeutic applications. This critical review will provide insights into the design, synthesis, functionalization, and applications of these artificial molecules in biomedicine and discuss their tailored interactions with biological systems to achieve improved patient health. Further, we provide a survey of the rapidly expanding body of literature on this topic and argue that gold nanotechnology-enabled biomedicine is not simply an act of ‘gilding the (nanomedicinal) lily’, but that a new ‘Golden Age’ of biomedical nanotechnology is truly upon us. Moving forward, the most challenging nanoscience ahead of us will be to find new chemical and physical methods of functionalizing gold nanoparticles with compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term term effects on human health and reproduction (472 references).
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影响因子：
15
作者：
Agasti SS;Chompoosor A;You CC;Ghosh P;Kim CK;Rotello VM
通讯作者：
Rotello VM
影响因子：
3.7
作者：
Banholzer, Matthew J.;Harris, Nadine;Mirkin, Chad A.
通讯作者：
Mirkin, Chad A.
影响因子：
3.9
作者：
Alkilany, Alaaldin M.;Frey, Rebecca L.;Murphy, Catherine J.
通讯作者：
Murphy, Catherine J.
DOI：
10.1073/pnas.0901715106
发表时间：
2009-04-07
影响因子：
11.1
作者：
Bonoiu, Adela C.;Mahajan, Supriya D.;Prasad, Paras N.
通讯作者：
Prasad, Paras N.
影响因子：
17.1
作者：
Au, Leslie;Zheng, Desheng;Zhou, Fei;Li, Zhi-Yuan;Li, Xingde;Xia, Younan
通讯作者：
Xia, Younan