Innate immune defenses: finding a new way to calm the storm.
Innate immune defenses: finding a new way to calm the storm.
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DOI：
10.1038/icb.2008.66
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发表时间：
2008-11
影响因子：
4
通讯作者：
Bakaletz, Lauren O.
中科院分区：
文献类型：
--
作者：
McGillivary, Glen;Bakaletz, Lauren O.
炎症反应是多细胞生物体保护自身免受微生物或其他刺激引起的细胞损伤的关键机制。在失调状态下，炎症也可能导致使人衰弱的病症如囊性纤维化、克罗恩病和哮喘的慢性化。1在最近的一项研究中，Pingel等人提供了一种新的机制的证据，该机制被宿主用于抑制牙周病期间观察到的炎症反应（图1），该炎症反应可能是由于促炎细菌分子的存在而导致的。这种抑制过程可能有助于维持组织的稳态2，并可能进一步有助于更好地治疗这种疼痛、衰弱和难看的疾病。宿主和定植在其粘膜表面的微生物都发展了控制和限制炎症反应的显著策略，每种策略都对自己有利（图2）。牙龈卟啉单胞菌是牙周病的主要病原体，牙周病是牙龈和周围组织的慢性多微生物炎性疾病，最终导致牙齿脱落。这种微生物表达大量蛋白酶、破坏性酶和粘附素，如血凝素B（HagB）蛋白。3此外，牙龈卟啉单胞菌利用几种手段来逃避免疫应答，例如产生脂多糖（LPS），其炎症性显著低于口腔中其他微生物的LPS。3
The inflammatory response is a critical mechanism used by multicellular organisms to protect themselves from cellular damage caused by microorganisms or other stimuli. In a dysregulated state, inflammation can also contribute to the chronicity of debilitating conditions such as cystic fibrosis, Crohn’s disease, and asthma. 1 In a recent study, Pingel et al. have provided evidence of a novel mechanism used by the host to dampen the inflammatory response observed during periodontal disease (Fig. 1) that can result due to the presence of pro-inflammatory bacterial molecules. This dampening process is likely to contribute to maintaining tissue homeostasis2 and might further lend itself to manipulation in order to better treat this painful, debilitating, and unsightly condition.Both the host, and microbes that colonize its mucosal surfaces, have developed remarkable strategies to control and limit the inflammatory response, each to their own benefit (Fig. 2). Porphyromonas gingivalis is a predominant etiological agent of periodontal disease, a chronic polymicrobial inflammatory disease of the gingiva and surrounding tissue that ultimately leads to tooth loss. This microorganism expresses an impressive array of proteases, destructive enzymes, and adhesins such as the hemagglutinin B (HagB) protein. 3 In addition, P. gingivalis utilizes several means to evade the immune response such as production of lipopolysaccharide (LPS) that is significantly less inflammatory than LPS of other microorganisms of the oral cavity. 3
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影响因子：
3.1
作者：
Pang, Bing;Winn, Dana;Swords, W. Edward
通讯作者：
Swords, W. Edward
影响因子：
4
作者：
Pingel, Lindsey C.;Kohlgraf, Karl G.;Brogden, Kim A.
通讯作者：
Brogden, Kim A.
影响因子：
3.1
作者：
Hong, Wenzhou;Mason, Kevin;Swords, W. Edward
通讯作者：
Swords, W. Edward
影响因子：
3.1
作者：
West-Barnette, S;Rockel, A;Swords, WE
通讯作者：
Swords, WE