Viral Nucleases from Herpesviruses and Coronavirus in Recombination and Proofreading: Potential Targets for Antiviral Drug Discovery.
Viral Nucleases from Herpesviruses and Coronavirus in Recombination and Proofreading: Potential Targets for Antiviral Drug Discovery.
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DOI：
10.3390/v14071557
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发表时间：
2022-07-16
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影响因子：
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在这篇综述中，我们探索了两个非常不同的病毒家族的重组，这两个病毒家族已经成为对人类健康的主要威胁。疱疹病毒科是一个致病双链DNA病毒大家族，与一系列影响人和动物的疾病有关。冠状病毒科是一种正链RNA病毒，特别是在过去20年里，它们也成为对全球健康和经济稳定的主要威胁。尽管人类疱疹病毒(HHV)和冠状病毒(CoV)在遗传物质(DNA和RNA)的组成和基因组复制的总体机制上存在许多差异，但它们的进化都严重依赖于重组来进行病毒基因组复制、适应新宿主和逃避宿主免疫调节。在这篇综述中，我们将重点介绍三种病毒外切酶的作用：两种HHV外切酶(碱性核酸酶和PolExo)和一种冠状病毒外切酶(外显子)。我们将回顾这三种核酸酶在它们各自的生命周期中的作用，并讨论针对这些靶点的药物发现工作的状况。
In this review, we explore recombination in two very different virus families that have become major threats to human health. The Herpesviridae are a large family of pathogenic double-stranded DNA viruses involved in a range of diseases affecting both people and animals. Coronaviridae are positive-strand RNA viruses (CoVs) that have also become major threats to global health and economic stability, especially in the last two decades. Despite many differences, such as the make-up of their genetic material (DNA vs. RNA) and overall mechanisms of genome replication, both human herpes viruses (HHVs) and CoVs have evolved to rely heavily on recombination for viral genome replication, adaptation to new hosts and evasion of host immune regulation. In this review, we will focus on the roles of three viral exonucleases: two HHV exonucleases (alkaline nuclease and PolExo) and one CoV exonuclease (ExoN). We will review the roles of these three nucleases in their respective life cycles and discuss the state of drug discovery efforts against these targets.
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DOI：
10.1042/bcj20210199
发表时间：
2021-07-16
期刊：
The Biochemical journal
影响因子：
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作者：
Canal B;Fujisawa R;McClure AW;Deegan TD;Wu M;Ulferts R;Weissmann F;Drury LS;Bertolin AP;Zeng J;Beale R;Howell M;Labib K;Diffley JFX
通讯作者：
Diffley JFX
影响因子：
7.6
作者：
Alam, Zohaib;Al-Mandi, Zainab;Zhu, Yali;McKee, Zachary;Parris, Deborah S.;Parikh, Hardik I.;Kellogg, Glen E.;Kuchta, Alison;McVoy, Michael A.
通讯作者：
McVoy, Michael A.
影响因子：
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作者：
Brandsma I;Gent DC
通讯作者：
Gent DC
影响因子：
4.9
作者：
Chou, Sunwen
通讯作者：
Chou, Sunwen
影响因子：
14.9
作者：
BAYLIS, SA;PURIFOY, DJM;LITTLER, E
通讯作者：
LITTLER, E