Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection.
Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection.
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DOI：
10.1016/j.jneuroim.2010.05.026
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发表时间：
2010-09-14
影响因子：
3.3
通讯作者：
Hildeman DA
中科院分区：
文献类型：
--
作者：
Lin AA;Wojciechowski SE;Hildeman DA
Intracranial (i.c.) lymphocytic choriomeningitis virus (LCMV) infection of mice results in T cell-driven anorexia and weight loss, which is diminished in males compared to females. We investigated sex-specific effects on antigen-presenting cells (APCs) and T cells after i.c. LCMV infection. Numbers of LCMV-specific T cells, APC activation, and levels of inflammatory cytokines and chemokines in CSF were decreased in males compared to females. Orchidectomy enhanced these immune parameters in males, while dihydrotestosterone treatment of orchidectomized males decreased some of these parameters. These data suggest that qualitative and quantitative effects of androgens on APCs and T cells may contribute to the well-known, but poorly understood sex differences in immunity and autoimmunity.
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